Big data approaches to decomposing heterogeneity across the autism spectrum

MV Lombardo, MC Lai, S Baron-Cohen - Molecular psychiatry, 2019 - nature.com
Autism is a diagnostic label based on behavior. While the diagnostic criteria attempt to
maximize clinical consensus, it also masks a wide degree of heterogeneity between and …

Classification and prediction of brain disorders using functional connectivity: promising but challenging

Y Du, Z Fu, VD Calhoun - Frontiers in neuroscience, 2018 - frontiersin.org
Brain functional imaging data, especially functional magnetic resonance imaging (fMRI)
data, have been employed to reflect functional integration of the brain. Alteration in brain …

Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder

AM Buch, PE Vértes, J Seidlitz, SH Kim… - Nature …, 2023 - nature.com
The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent …

Gender imbalance in medical imaging datasets produces biased classifiers for computer-aided diagnosis

AJ Larrazabal, N Nieto, V Peterson… - Proceedings of the …, 2020 - National Acad Sciences
Artificial intelligence (AI) systems for computer-aided diagnosis and image-based screening
are being adopted worldwide by medical institutions. In such a context, generating fair and …

Fastsurfer-a fast and accurate deep learning based neuroimaging pipeline

L Henschel, S Conjeti, S Estrada, K Diers, B Fischl… - NeuroImage, 2020 - Elsevier
Traditional neuroimage analysis pipelines involve computationally intensive, time-
consuming optimization steps, and thus, do not scale well to large cohort studies with …

rs-fMRI and machine learning for ASD diagnosis: a systematic review and meta-analysis

CP Santana, EA de Carvalho, ID Rodrigues… - Scientific reports, 2022 - nature.com
Abstract Autism Spectrum Disorder (ASD) diagnosis is still based on behavioral criteria
through a lengthy and time-consuming process. Much effort is being made to identify brain …

Contrastive machine learning reveals the structure of neuroanatomical variation within autism

A Aglinskas, JK Hartshorne, S Anzellotti - Science, 2022 - science.org
Autism spectrum disorder (ASD) is highly heterogeneous. Identifying systematic individual
differences in neuroanatomy could inform diagnosis and personalized interventions. The …