The ovarian follicle is the basic functional unit of the ovary, comprising theca cells and
granulosa cells (GCs). Two different types of GCs, mural GCs and cumulus cells (CCs) …

Gonadal development is a complex process that involves sex determination followed by
divergent maturation into either testes or ovaries. Historically, limited tissue accessibility, a …

Unlike most epithelial malignancies which metastasize hematogenously, metastasis of
epithelial ovarian cancer (EOC) occurs primarily via transcoelomic dissemination …

Cancer-associated fibroblasts (CAF) are a major constituent of the tumor stroma, but little is
known about how cancer cells transform normal fibroblasts into CAFs. microRNAs (miRNA) …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Intense
efforts have been made to elucidate the pathogeny, but the molecular mechanisms of HCC …

A cell line representative of human high-grade serous ovarian cancer (HGSOC) should not
only resemble its tumour of origin at the molecular level, but also demonstrate functional …

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic
variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of …

Epithelial ovarian cancer (EOC) is hallmarked by a high degree of heterogeneity. To
address this heterogeneity, a classification scheme was developed based on gene …

RNA-binding proteins (RBPs) are increasingly identified as post-transcriptional drivers of
cancer progression. The RBP LARP1 is an mRNA stability regulator, and elevated …

Recently, identifying robust biomarkers or signatures from gene expression profiling data
has attracted much attention in computational biomedicine. The successful discovery of …