Chemical glycoproteomics

KK Palaniappan, CR Bertozzi - Chemical reviews, 2016 - ACS Publications
Chemical tools have accelerated progress in glycoscience, reducing experimental barriers
to studying protein glycosylation, the most widespread and complex form of posttranslational …

Recent advances in the mass spectrometry methods for glycomics and cancer

MJ Kailemia, G Xu, M Wong, Q Li… - Analytical …, 2017 - pmc.ncbi.nlm.nih.gov
The review focuses on recent aspects (last three years) of glycosylation analyses that
provide relevant information about cancer. It includes recent development in glycan and …

Cell membrane–camouflaged liposomes for tumor cell–selective glycans engineering and imaging in vivo

Z Liu, F Wang, X Liu, Y Sang, L Zhang, J Ren… - Proceedings of the …, 2021 - pnas.org
The dynamic change of cell-surface glycans is involved in diverse biological and
pathological events such as oncogenesis and metastasis. Despite tremendous efforts, it …

Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers

G Tardif, F Paré, C Gotti, F Roux-Dalvai, A Droit… - Arthritis research & …, 2022 - Springer
Background Osteoarthritis (OA) is a slowly develo** and debilitating disease, and there
are no validated specific biomarkers for its early detection. To improve therapeutic …

Map** the cancer surface proteome in search of target antigens for immunotherapy

F Di Meo, B Kale, JM Koomen, F Perna - Molecular Therapy, 2024 - cell.com
Immune-based therapeutic interventions recognizing proteins localized on the cell surface of
cancer cells are emerging as a promising cancer treatment. Antibody-based therapies and …

LncRNA PSMA3‐AS1 promotes cell proliferation, migration, and invasion in ovarian cancer by activating the PI3K/Akt pathway via the miR‐378a‐3p/GALNT3 axis

Z Xu, H **, X Duan, H Liu, X Zhao, S Fan… - Environmental …, 2021 - Wiley Online Library
The crucial roles of the long noncoding RNAs (lncRNAs) in the development of ovarian
cancer (OC) have been extensively studied. According to the prediction result from the …

Chemical proteomics to study metabolism, a reductionist approach applied at the systems level

MY Ali, L Bar-Peled - Cell Chemical Biology, 2024 - cell.com
Cellular metabolism encompasses a complex array of interconnected biochemical pathways
that are required for cellular homeostasis. When dysregulated, metabolism underlies …

Glycobiology modifications in intratumoral hypoxia: the breathless side of glycans interaction

AF Silva-Filho, WLB Sena, LRA Lima… - Cellular physiology and …, 2017 - karger.com
Post-translational and co-translational enzymatic addition of glycans (glycosylation) to
proteins, lipids, and other carbohydrates, is a powerful regulator of the molecular machinery …

Downregulation of circ‐RAPGEF5 inhibits colorectal cancer progression by reducing the expression of polypeptide N‐acetylgalactosaminyltransferase 3 (GALNT3)

D Cheng, F Chu, F Liang, N Zhang… - Environmental …, 2024 - Wiley Online Library
Abstract Background Circular RNA (circRNA) plays a crucial role in the pathogenesis and
progression of colorectal cancer (CRC). However, the current understanding of the …

Altered expression of different GalNAc-transferases is associated with disease progression and poor prognosis in women with high-grade serous ovarian cancer

R Sheta, M Bachvarova, M Plante… - International …, 2017 - spandidos-publications.com
Protein glycosylation perturbations are implicated in a variety of diseases, including cancer.
Aberrant glycosylation in cancer is frequently attributed to altered expression of polypeptide …