Anti-inflammatory and neuroprotective agents in clinical trials for CNS disease and injury: where do we go from here?

K Mallah, C Couch, DM Borucki, A Toutonji… - Frontiers in …, 2020 - frontiersin.org
Neurological disorders are major contributors to death and disability worldwide. The
pathology of injuries and disease processes includes a cascade of events that often involve …

Effects of disease-modifying therapy on peripheral leukocytes in patients with multiple sclerosis

F Schweitzer, S Laurent, GR Fink, MH Barnett… - Journal of …, 2021 - Springer
Modern disease-modifying therapies (DMTs) in multiple sclerosis (MS) have variable modes
of action and selectively suppress or modulate the immune system. In this review, we …

Considering patient clinical history impacts performance of machine learning models in predicting course of multiple sclerosis

R Seccia, D Gammelli, F Dominici, S Romano… - PloS one, 2020 - journals.plos.org
Multiple Sclerosis (MS) progresses at an unpredictable rate, but predictions on the disease
course in each patient would be extremely useful to tailor therapy to the individual needs …

Sustained in vitro interferon-beta release and in vivo toxicity of PLGA and PEG-PLGA nanoparticles

A Fodor-Kardos, ÁF Kiss, K Monostory, T Feczkó - RSC advances, 2020 - pubs.rsc.org
Interferon-beta-1a (IFN-β-1a) can diminish the symptoms of relapsing-remitting multiple
sclerosis. Herein, we prepared sustained drug delivery IFN-β-1a-loaded nanoparticles by a …

Nitric oxide involvement in the disability and active disease of multiple sclerosis: Systematic review and meta-analysis

B da Silva, FT Viero, P Rodrigues, G Trevisan - Nitric Oxide, 2024 - Elsevier
Background Multiple sclerosis (MS) is a chronic and immune-mediated disease of unknown
etiology and leading to a physical and cognitive disability. Different studies suggest that …

Eighteen-month safety analysis of offspring breastfed by mothers receiving glatiramer acetate therapy for relapsing multiple sclerosis–COBRA study

AI Ciplea, A Kurzeja, S Thiel, S Haben… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: Safety data on disease-modifying therapies (DMTs) for relapsing multiple
sclerosis (RMS) during breastfeeding are limited. Objective: Assess safety outcomes for …

Advanced oxidative protein products role in multiple sclerosis: A systematic review and meta-analysis

P Rodrigues, GV Bochi, G Trevisan - Molecular Neurobiology, 2021 - Springer
Multiple sclerosis (MS) is an autoimmune-mediated disease that damages the central
nervous system. MS pathophysiological features are not entirely understood, but the …

Vitamin D changes expression of DNA repair genes in the patients with multiple sclerosis

R Amirinejad, Z Shirvani-Farsani, BN Gargari… - Gene, 2021 - Elsevier
Oxidative stress (OS) plays an essential role in demyelination and tissue injury related to
pathogenesis of multiple sclerosis (MS). On the other hand, vitamin D (VD) as an antioxidant …

[HTML][HTML] Potential Crosstalk between the PACAP/VIP Neuropeptide System and Endoplasmic Reticulum Stress—Relevance to Multiple Sclerosis Pathophysiology

M Withana, A Castorina - Cells, 2023 - mdpi.com
Multiple sclerosis (MS) is an immune-mediated disorder characterized by focal
demyelination and chronic inflammation of the central nervous system (CNS). Although the …

Antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1 contribute to neuronal cell loss in an animal model of multiple sclerosis

CD Libner, HE Salapa, C Hutchinson… - Journal of …, 2020 - Wiley Online Library
Neurodegeneration, including loss of neurons and axons, is a feature of progressive forms
of multiple sclerosis (MS). The mechanisms underlying neurodegeneration are mostly …