Lissencephaly ('smooth brain') is a severe brain disease associated with numerous
symptoms, including cognitive impairment, and shortened lifespan. The main causative …

Several malformation syndromes with abnormal cortical development have been
recognized. Specific causative gene defects and characteristic electroclinical patterns have …

An enriched environment is known to promote structural changes in the brain and to
enhance learning and memory performance in rodents [Hebb, DO (1947) Am. Psychol. 2 …

Mutations in the LIS1 gene cause gross histological disorganization of the develo**
human brain, resulting in a brain surface that is almost smooth. Here we show that LIS1 …

Malformations of the cerebral cortex (MCC) are often associated with severe epilepsy and
developmental delay. About 40% of drug‐resistant epilepsies are caused by MCC …

Lissencephaly is a severe brain malformation in humans. To study the function of the gene
mutated in lissencephaly (LIS1), we deleted the first coding exon from the mouse Lis1 gene …

The etiology of schizophrenia likely involves genetic interactions. DISC1, a promising
candidate susceptibility gene, encodes a protein which interacts with many other proteins …

Classical lissencephaly (LIS) and subcortical band heterotopia (SBH) are related cortical
malformations secondary to abnormal migration of neurons during early brain development …

Malformations of the cerebral cortex are an important cause of developmental disabilities
and epilepsy. Here we review those malformations for which a genetic basis has been …

We reviewed the epileptogenic cortical malformations for which a causative gene has been
cloned or a linkage obtained. X‐linked bilateral periventricular nodular heterotopia (BPNH) …