Bioactive lipids, inflammation and chronic diseases
A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …
cellular and molecular processes involved in health and disease, of which inflammation …
Ceramides in autoimmune rheumatic diseases: existing evidence and therapeutic considerations for diet as an anticeramide treatment
Autoimmune rheumatic diseases (AIRDs) constitute a set of connective tissue disorders and
dysfunctions with akin clinical manifestations and autoantibody responses. AIRD treatment …
dysfunctions with akin clinical manifestations and autoantibody responses. AIRD treatment …
Sphingosine 1-phosphate signaling during infection and immunity
Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …
S1P increases VEGF production in osteoblasts and facilitates endothelial progenitor cell angiogenesis by inhibiting miR-16-5p expression via the c-Src/FAK signaling …
Angiogenesis is a critical process in the formation of new capillaries and a key participant in
rheumatoid arthritis (RA) pathogenesis. Vascular endothelial growth factor (VEGF) …
rheumatoid arthritis (RA) pathogenesis. Vascular endothelial growth factor (VEGF) …
the sphingosine 1 phosphate/sphingosine 1 phosphate receptor axis‐a unique therapeutic target in inflammatory bowel disease
J Wang, I Goren, B Yang, S Lin, J Li… - Alimentary …, 2022 - Wiley Online Library
Background Ozanimod, a high selective sphingosine 1 phosphate (S1P) receptor (S1PR)
1/5 modulator was approved by the Food and Drug Administration for the treatment of adult …
1/5 modulator was approved by the Food and Drug Administration for the treatment of adult …
Functional lipids in autoimmune inflammatory diseases
Lipids are apolar small molecules known not only as components of cell membranes but
also, in recent literature, as modulators of different biological functions. Herein, we focused …
also, in recent literature, as modulators of different biological functions. Herein, we focused …
Lipids in liver failure syndromes: a focus on eicosanoids, specialized pro-resolving lipid mediators and lysophospholipids
Lipids are organic compounds insoluble in water with a variety of metabolic and non-
metabolic functions. They not only represent an efficient energy substrate but can also act as …
metabolic functions. They not only represent an efficient energy substrate but can also act as …
Comparison of immune cells and diagnostic markers between spondyloarthritis and rheumatoid arthritis by bioinformatics analysis
J Wang, Y Xue, L Zhou - Journal of Translational Medicine, 2022 - Springer
Abstract Background Spondyloarthritis (SpA) and rheumatoid arthritis (RA) are chronic
autoimmune diseases, but they are usually difficult to distinguish in the early stage of the …
autoimmune diseases, but they are usually difficult to distinguish in the early stage of the …
[HTML][HTML] S1P/S1PR signaling pathway advancements in autoimmune diseases
J Li, Y Huang, Y Zhang, P Liu, M Liu… - Biomolecules and …, 2023 - ncbi.nlm.nih.gov
Abstract Sphingosine-1-phosphate (S1P) is a versatile sphingolipid that is generated
through the phosphorylation of sphingosine by sphingosine kinase (SPHK). S1P exerts its …
through the phosphorylation of sphingosine by sphingosine kinase (SPHK). S1P exerts its …
[HTML][HTML] Broad and diverse roles of sphingosine-1-phosphate/sphingosine-1-phosphate receptors in the prostate
D Liu, J Liu, Y Li, L Du, Q Cao, L Yang, Y Zhou, P Chen… - iScience, 2024 - cell.com
Benign prostatic hyperplasia (BPH) is a common condition in aging males, but its underlying
pathogenesis remains unclear. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) …
pathogenesis remains unclear. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) …