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Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
The pan-immune system of bacteria: antiviral defence as a community resource
Viruses and their hosts are engaged in a constant arms race leading to the evolution of
antiviral defence mechanisms. Recent studies have revealed that the immune arsenal of …
antiviral defence mechanisms. Recent studies have revealed that the immune arsenal of …
Positive and negative aspects of bacteriophages and their immense role in the food chain
Bacteriophages infect and replicate inside a bacterial host as well as serve as natural bio-
control agents. Phages were once viewed as nuisances that caused fermentation failures …
control agents. Phages were once viewed as nuisances that caused fermentation failures …
Mechanisms of action of plant growth promoting bacteria
The idea of eliminating the use of fertilizers which are sometimes environmentally unsafe is
slowly becoming a reality because of the emergence of microorganisms that can serve the …
slowly becoming a reality because of the emergence of microorganisms that can serve the …
An overview of the public health challenges in diagnosing and controlling human foodborne pathogens
Pathogens found in food are believed to be the leading cause of foodborne illnesses; and
they are considered a serious problem with global ramifications. During the last few …
they are considered a serious problem with global ramifications. During the last few …
Phages for phage therapy: isolation, characterization, and host range breadth
P Hyman - Pharmaceuticals, 2019 - mdpi.com
For a bacteriophage to be useful for phage therapy it must be both isolated from the
environment and shown to have certain characteristics beyond just killing strains of the …
environment and shown to have certain characteristics beyond just killing strains of the …
Contemporary phage biology: from classic models to new insights
Bacteriophages, discovered about a century ago, have been pivotal as models for
understanding the fundamental principles of molecular biology. While interest in phage …
understanding the fundamental principles of molecular biology. While interest in phage …
Phage-specific metabolic reprogramming of virocells
Ocean viruses are abundant and infect 20–40% of surface microbes. Infected cells, termed
virocells, are thus a predominant microbial state. Yet, virocells and their ecosystem impacts …
virocells, are thus a predominant microbial state. Yet, virocells and their ecosystem impacts …
Secondary bacterial infections in patients with viral pneumonia
Pulmonary diseases of viral origin are often followed by the manifestation of secondary
infections, leading to further clinical complications and negative disease outcomes. Thus …
infections, leading to further clinical complications and negative disease outcomes. Thus …
[HTML][HTML] In vitro techniques and measurements of phage characteristics that are important for phage therapy success
T Glonti, JP Pirnay - Viruses, 2022 - mdpi.com
Validated methods for phage selection, host range expansion, and lytic activity
determination are indispensable for maximizing phage therapy outcomes. In this review, we …
determination are indispensable for maximizing phage therapy outcomes. In this review, we …