Pyrrole: An emerging scaffold for construction of valuable therapeutic agents

SS Gholap - European journal of medicinal chemistry, 2016 - Elsevier
Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which
can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti …

Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1, 3, 4-oxadiazole derivatives as potential antitubercular …

NC Desai, H Somani, A Trivedi, K Bhatt… - Bioorganic & medicinal …, 2016 - Elsevier
A series of indole and pyridine based 1, 3, 4-oxadiazole derivatives 5a–t were synthesized
and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H …

1, 3, 4‐oxadiazole derivatives as potential antimicrobial agents

D Tiwari, R Narang, K Sudhakar… - Chemical Biology & …, 2022 - Wiley Online Library
Due to the emergence of drug‐resistant microbial strains, different research groups are
continuously develo** novel drug molecules against already exploited and unexploited …

Synthesis and antitubercular activity of new 1, 3, 4-oxadiazoles bearing pyridyl and thiazolyl scaffolds

ST Dhumal, AR Deshmukh, MR Bhosle… - Bioorganic & Medicinal …, 2016 - Elsevier
In search of more potent and safe new antitubercular agents, here new 2-pyridinyl
substituted thiazolyl-5-aryl-1, 3, 4-oxadiazoles (6a–o), have been designed and synthesized …

Design, synthesis and biological evaluation of (E)-5-styryl-1, 2, 4-oxadiazoles as anti-tubercular agents

AA Upare, PK Gadekar, H Sivaramakrishnan, N Naik… - Bioorganic …, 2019 - Elsevier
Cinnamic acid and its derivatives are known for anti-tubercular activity. The present study
reports the synthesis of cinnamic acid derivatives via bioisosteric replacement of terminal …

Conventional and microwave-assisted synthesis, antitubercular activity, and molecular docking studies of pyrazole and oxadiazole hybrids

NC Desai, K Bhatt, J Monapara, U Pandit… - ACS …, 2021 - ACS Publications
Microwave-assisted organic reaction enhancement (MORE) has become more important in
synthetic organic chemistry for efficient resource utilization. In this study, we synthesized …

Synthesis, biological evaluation, and molecular docking study of pyridine clubbed 1, 3, 4-oxadiazoles as potential antituberculars

NC Desai, A Trivedi, H Somani, KA Jadeja… - Synthetic …, 2018 - Taylor & Francis
ABSTRACT A series of pyridine clubbed 1, 3, 4-oxadiazole derivatives were efficiently
synthesized, characterized by standard spectral techniques and evaluated for their in vitro …

[HTML][HTML] 2D-Quantitative structure activity relationship (QSAR) modeling, docking studies, synthesis and in-vitro evaluation of 1, 3, 4-thiadiazole tethered coumarin …

N Ramalakshmi, P Manimegalai, RR Bhandare… - Journal of Saudi …, 2021 - Elsevier
Cancer is one of the leading causes of deaths globally. Despite many anticancer agents in
the market, cancer stood as a major health concern to humanity due to the problems like …

Synthesis, characterization and evaluation of cytotoxic and antioxidant activities of dihydropyrimidone substituted pyrrole derivatives

A Khalilpour, S Asghari - Medicinal Chemistry Research, 2018 - Springer
Dihydropyrimidones substituted pyrrole were prepared in high yields from three-component
coupling of alkyl isocyanides, dialkyl acetylenedicarboxylates and dihydropyrimidone …

Synthesis of novel 5‐oxo‐1, 2, 4‐oxadiazole derivatives as antitubercular agents and their molecular docking study toward enoyl reductase (InhA) enzyme

BRS Reddy, KS Babu, N Mulakayala… - …, 2023 - Wiley Online Library
Abstract An analogue of novel 3‐(1‐(4‐(benzoyl) benzyl)‐1H‐indol‐5‐yl)‐1, 2, 4‐oxadiazol‐
5 (4H)‐ones were synthesized in good yields (80–90%), and its anti‐tubercular (anti‐TB) …