Drug resistance is a major obstacle in the field of pre-clinical and clinical therapeutics. The
development of novel technologies and targeted therapies have yielded new modalities to …

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis,
chemoresistance and metastasis. While eliminating this subpopulation of cells would …

The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a
plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a …

The mesenchymal (MES) subtype of glioblastoma (GBM) is a highly aggressive, malignant
and proliferative cancer that is resistant to chemotherapy. Runt-related transcription factor 1 …

Cancer remains a life-threatening disease and accounts for the major mortality rates
worldwide. The practice of using biomarkers for early detection, staging, and customized …

Glioblastoma (GB) remains a formidable challenge and requires new treatment strategies.
The vital part of the Ubiquitin-proteasome system (UPS) in cellular regulation has positioned …

USP8 is a deubiquitinating enzyme in the family of ubiquitin-specific proteases (USPs)
which can remove ubiquitin from the substrate and protect the substrate from degradation …

Most proteins undergo posttranslational modification such as acetylation, methylation,
phosphorylation, biotinylation, and ubiquitination to regulate various cellular processes …