The multicomponent Mannich reaction is a green and classical method for the preparation of
β-aminoketones and β-aminoaldehydes (Mannich bases) and, as such, is one of the most …

Naphthoquinones are the most commonly occurring type of quinones in nature. They are a
diverse family of secondary metabolites that occur naturally in plants, lichens and various …

Cochlospermum regium is a shrub used in folk medicine to treat infection diseases.
However, limited information are available regarding the antimicrobial mechanism of action …

Vulvovaginal candidiasis (VVC) affects millions of women around the world every year.
Candida albicans is the most frequently isolated pathogen in women and its rapid ability to …

The increase of opportunistic fungal infections raises the need for design and synthesis of
new antifungal agents. Taking into account that tetrazole derivatives exhibit antifungal …

Lawsone (2-hydroxynaphthalene-1, 4-dione) is a natural product which shows significant
biological activity. Aminomethylnaphthoquinone Mannich bases derived from lawsone …

Naphthoquinone derivatives are a class of organic compounds that interact with many
biological systems. Now it is found that the use of naphthoquinone derivatives against …

Background Candida albicans is the main agent that causes vulvovaginal candidiasis.
Resistance among isolates to azole antifungal agents has been reported. Aims Due to the …

A green and operationally simple approach for the library synthesis of novel bis-
heteroarylaminomethylnaphthoquinone derivatives by a one-pot pseudo five-component …

This study reports on the one‐step, green, catalyst‐free synthesis of new naphthoquinone‐
polyphenols through an innovative method using the multicomponent domino Mannich …