Regulation of mTORC1 by PI3K signaling
CC Dibble, LC Cantley - Trends in cell biology, 2015 - cell.com
The class I phosphoinositide 3-kinase (PI3K)–mechanistic target of rapamycin (mTOR)
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
J Huang, BD Manning - Biochemical Journal, 2008 - portlandpress.com
TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC
(tuberous sclerosis complex). Their gene products form a complex that has become the …
(tuberous sclerosis complex). Their gene products form a complex that has become the …
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by the formation
of hamartomas in a wide range of human tissues. Mutation in either the TSC1 or TSC2 …
of hamartomas in a wide range of human tissues. Mutation in either the TSC1 or TSC2 …
[HTML][HTML] TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
CC Dibble, W Elis, S Menon, W Qin, J Klekota… - Molecular cell, 2012 - cell.com
The tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 complex,
which limits cell growth in response to poor growth conditions. Through its GTPase …
which limits cell growth in response to poor growth conditions. Through its GTPase …
[HTML][HTML] IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
TNFα has recently emerged as a regulator linking inflammation to cancer pathogenesis, but
the detailed cellular and molecular mechanisms underlying this link remain to be elucidated …
the detailed cellular and molecular mechanisms underlying this link remain to be elucidated …
Nutrient signaling to mTOR and cell growth
JL Jewell, KL Guan - Trends in biochemical sciences, 2013 - cell.com
The mammalian target of rapamycin (mTOR) is a conserved protein kinase involved in a
multitude of cellular processes including cell growth. Increased mTOR activation is observed …
multitude of cellular processes including cell growth. Increased mTOR activation is observed …
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
J Huang, CC Dibble, M Matsuzaki… - Molecular and cellular …, 2008 - Taylor & Francis
The mammalian target of rapamycin (mTOR) is a protein kinase that forms two functionally
distinct complexes important for nutrient and growth factor signaling. Both complexes …
distinct complexes important for nutrient and growth factor signaling. Both complexes …
Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling
X Gao, Y Zhang, P Arrazola, O Hino, T Kobayashi… - Nature cell …, 2002 - nature.com
Target of Rapamycin (TOR) mediates a signalling pathway that couples amino acid
availability to S6 kinase (S6K) activation, translational initiation and cell growth,. Here, we …
availability to S6 kinase (S6K) activation, translational initiation and cell growth,. Here, we …
The tuberous sclerosis complex
KA Orlova, PB Crino - Annals of the New York Academy of …, 2010 - Wiley Online Library
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that results from
mutations in the TSC1 or TSC2 genes and is associated with hamartoma formation in …
mutations in the TSC1 or TSC2 genes and is associated with hamartoma formation in …
mTOR signaling in stem and progenitor cells
D Meng, AR Frank, JL Jewell - Development, 2018 - journals.biologists.com
The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to
coordinate cell growth, metabolism and autophagy. Extensive research has mapped the …
coordinate cell growth, metabolism and autophagy. Extensive research has mapped the …