Current status of mannose receptor-targeted drug delivery for improved anti-HIV therapy

S Rojekar, AD Gholap, N Togre, P Bhoj… - Journal of Controlled …, 2024 - Elsevier
In the pursuit of achieving better therapeutic outcomes in the treatment of HIV, innovative
drug delivery strategies have been extensively explored. Mannose receptors, which are …

Lectin-glycan interactions: a comprehensive cataloguing of cancer-associated glycans for biorecognition and bio-alteration: a review

MJ Gurav, J Manasa, AS Sanji, PH Megalamani… - Glycoconjugate …, 2024 - Springer
This comprehensive review meticulously compiles data on an array of lectins and their
interactions with different cancer types through specific glycans. Crucially, it establishes the …

Water–glycan interactions drive the SARS-CoV-2 spike dynamics: insights into glycan-gate control and camouflage mechanisms

M Blazhynska, L Lagardère, C Liu, O Adjoua… - Chemical …, 2024 - pubs.rsc.org
To develop therapeutic strategies against COVID-19, we introduce a high-resolution all-
atom polarizable model capturing many-body effects of protein, glycan, solvent, and …

[HTML][HTML] Identification of a Novel Antiviral Lectin against SARS-CoV-2 Omicron Variant from Shiitake-Mushroom-Derived Vesicle-like Nanoparticles

J Wiggins, SU Karim, B Liu, X Li, Y Zhou, F Bai, J Yu… - Viruses, 2024 - mdpi.com
Lectins are a class of carbohydrate-binding proteins that may have antiviral activity by
binding to the glycans on the virion surface to interfere with viral entry. We have identified a …

[HTML][HTML] Isolation and structure elucidation of Dm-CVNH, a new cyanovirin-N homolog with activity against SARS-CoV-2 and HIV-1

M Orfanoudaki, LRH Krumpe, SR Shenoy… - Journal of Biological …, 2025 - Elsevier
An anti-HIV screening of natural product extracts resulted in the discovery of a new antiviral
protein through bioassay-guided fractionation of an aqueous extract of the ascidian …

Anti-staphylococcal, antibiofilm and trypanocidal activities of CrataBL encapsulated into liposomes: Lectin with potential against infectious diseases

LA de Almeida Campos, SD da Costa Junior… - Microbial …, 2024 - Elsevier
The present study aimed to evaluate the anti-staphylococcal, antibiofilm, cytotoxicity and
trypanocidal activity, mechanisms of parasite death and immunomodulatory effect of …

Adaptive mechanisms to hypoxia and hyperoxia in juvenile turbot, Scophthalmus maximus

Y Chen, Y Zhang, R Zhang, H Deng, X Meng… - Frontiers in Marine …, 2024 - frontiersin.org
In recirculating aquaculture systems (RAS), the impact of dissolved oxygen (DO) fluctuations
on turbot is still not fully understood. This study investigated these impacts by selecting 135 …

Lectins: Versatile proteins in plant life with diverse applications in immunomodulation, antibacterial defense, and disease-fighting

S Jeyachandran, P Vibhute - Journal of Carbohydrate Chemistry, 2024 - Taylor & Francis
Lectins, diverse proteins adept at detecting and binding carbohydrates without altering them,
are pivotal in plant life. They facilitate cell communication, development, and defense …