Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …

Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …

Purpose Blinatumomab, a bispecific single-chain antibody targeting the CD19 antigen, is a
member of a novel class of antibodies that redirect T cells for selective lysis of tumor cells. In …

Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T
cell receptor (TCR) affinity to the relevant pathogen-associated antigens. However, low …

To understand why cancer vaccine–induced T cells often do not eradicate tumors, we
studied immune responses in mice vaccinated with gp100 melanoma peptide in incomplete …

Haematopoietic stem cells (HSCs) and their subsequent progenitors produce blood cells,
but the precise nature and kinetics of this production is a contentious issue. In one model …

Cellular barcoding is a technique in which individual cells are labeled with unique nucleic
acid sequences, termed barcodes, so that they can be tracked through space and time …

Upon infection, antigen-specific CD8+ T lymphocyte responses display a highly
reproducible pattern of expansion and contraction that is thought to reflect a uniform …

Disentangling cellular heterogeneity is a challenge in many fields, particularly in the stem
cell and cancer biology fields. Here we demonstrate how to combine viral genetic barcoding …