Liquid biopsy: from discovery to clinical application

C Alix-Panabières, K Pantel - Cancer discovery, 2021 - AACR
Over the past 10 years, circulating tumor cells (CTC) and circulating tumor DNA (ctDNA)
have received enormous attention as new biomarkers and subjects of translational research …

Circulating tumour cells for early detection of clinically relevant cancer

R Lawrence, M Watters, CR Davies, K Pantel… - Nature Reviews Clinical …, 2023 - nature.com
Given that cancer mortality is usually a result of late diagnosis, efforts in the field of early
detection are paramount to reducing cancer-related deaths and improving patient outcomes …

Novel approaches to target the microenvironment of bone metastasis

LC Hofbauer, A Bozec, M Rauner, F Jakob… - Nature reviews Clinical …, 2021 - nature.com
Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively …

The potential of liquid biopsy in the management of cancer patients

A Markou, E Tzanikou, E Lianidou - Seminars in cancer biology, 2022 - Elsevier
Over the last decade, liquid biopsy has gained much attention as a powerful tool in
personalized medicine, since it enables monitoring cancer evolution and follow-up of cancer …

Multi-stage mechanisms of tumor metastasis and therapeutic strategies

Z Liu, J Chen, Y Ren, S Liu, Y Ba, A Zuo… - … and Targeted Therapy, 2024 - nature.com
The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade

Z Eslami-S, LE Cortes-Hernandez, F Thomas… - British Journal of …, 2022 - nature.com
Metastasis formation is the main cause of cancer-related death in patients with solid
tumours. At the beginning of this process, cancer cells escape from the primary tumour to the …

Updates on liquid biopsy: Current trends and future perspectives for clinical application in solid tumors

P Pinzani, V D'Argenio, M Del Re… - Clinical Chemistry and …, 2021 - degruyter.com
Despite advances in screening and therapeutics cancer continues to be one of the major
causes of morbidity and mortality worldwide. The molecular profile of tumor is routinely …

[HTML][HTML] Crucial roles of circulating tumor cells in the metastatic cascade and tumor immune escape: biology and clinical translation

K Pantel, C Alix-Panabières - Journal for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Cancer-related deaths are mainly caused by metastatic spread of tumor cells from the
primary lesion to distant sites via the blood circulation. Understanding the mechanisms of …

Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels

SP Leong, K Naxerova, L Keller, K Pantel… - Clinical & Experimental …, 2022 - Springer
Cancer metastasis is the process by which primary cancer cells invade through the
lymphatic or blood vessels to distant sites. The molecular mechanisms by which cancer cells …

Epithelial cell adhesion molecule: an anchor to isolate clinically relevant circulating tumor cells

In the last few decades, the epithelial cell adhesion molecule (EpCAM) has received
increased attention as the main membrane marker used in many enrichment technologies to …