Choline supplements: An update

U Kansakar, V Trimarco, P Mone, F Varzideh… - Frontiers in …, 2023 - frontiersin.org
In this comprehensive review, we examine the main preclinical and clinical investigations
assessing the effects of different forms of choline supplementation currently available …

Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model …

A Munafò, AF Cantone, G Di Benedetto… - Frontiers in …, 2024 - frontiersin.org
Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disorder
affecting the elderly population worldwide. Due to the multifactorial nature of the disease …

Taming microglia in Alzheimer's disease: exploring potential implications of choline alphoscerate via α7 nAChR modulation

AF Cantone, C Burgaletto, G Di Benedetto… - Cells, 2024 - mdpi.com
Alzheimer's disease (AD), marked by cognitive impairment, predominantly affects the brain
regions regulated by cholinergic innervation, such as the cerebral cortex and hippocampus …

Safety evaluation of alpha-glycerylphosphorylcholine as a novel food

J Tian, X Ke, Y Zhang, J Qu, S Fu, Y **a, W Yang… - Food and Chemical …, 2025 - Elsevier
To evaluate the safety of alpha-glycerylphosphorylcholine (α-GPC) as a novel food, the
study of acute oral toxicity, subchronic toxicity, teratogenic toxicity and genotoxicity were …

[HTML][HTML] Potential risk of choline alfoscerate on isoflurane-induced toxicity in primary human astrocytes

HJ Lee, HR Cho, M Bang, YS Lee… - Journal of Korean …, 2023 - synapse.koreamed.org
Objective Isoflurane, a widely used common inhalational anesthetic agent, can induce brain
toxicity. The challenge lies in protecting neurologically compromised patients from …

Effetti della Colina Alfoscerato sulla neurotossicità in un modello di malattia di Alzheimer

PG Tarro - 2023 - tesidottorato.depositolegale.it
Alzheimer's disease (AD) is the most common cause of dementia worldwide, characterized
by extreme unmet needs and a huge disease burden. Cerebral atrophy, amyloid plaques …