Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Despite recent advances in cancer therapy, current treatments, including radiotherapy,
chemotherapy, and immunotherapy, although beneficial, present attendant side effects and …

Blood-brain barrier (BBB) serves as an essential interface between central nervous system
(CNS) and its periphery, allowing selective permeation of ions, gaseous molecules, and …

Background Shikonin is one of the major phytochemical components of Lithospermum
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …

Alzheimer's disease, a progressive neurodegenerative condition, is characterized by a
gradual decline in cognitive functions. Current treatment approaches primarily involve the …

Background Controlled release and targeted delivery of the drug payload are the two most
fascinating applications of nanoparticle-based systems explored in the recent past. The …

Milk proteins and the products of their hydrolysis are characterised by high levels of
biological activity. The health-promoting potential of bovine milk proteins, peptides and …

Gliomas are the most common tumor of the central nervous system. However, the presence
of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of …

Malignant tumor, the leading cause of death worldwide, poses a serious threat to human
health. For decades, natural product has been proven to be an essential source for novel …