Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most
versatile family of membrane receptors, are also the most common target of therapeutic …

β-arrestins are versatile adapter proteins that form complexes with most G-protein-coupled
receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein …

The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …

▪ Abstract Dynamin, a 100-kDa GTPase, is an essential component of vesicle formation in
receptor-mediated endocytosis, synaptic vesicle recycling, caveolae internalization, and …

▪ Abstract There has recently been considerable progress in understanding the regulation of
clathrin-coated vesicle (CCV) formation and function. These advances are due to the …

Clathrin‐coated pits and caveolae are two of the most recognizable features of the plasma
membrane of mammalian cells. While our understanding of the machinery regulating and …

The contribution of prolactin (PRL) to the pathogenesis and progression of human breast
cancer at the cellular, transgenic, and epidemiological levels is increasingly appreciated …

Sequestration of G protein-coupled receptors from the cell surface is a commonly observed
phenomenon following agonist-stimulation. This process is now believed to be important for …