Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

Viral vectors are promising tools for gene therapy and vaccines. Viral vector-based vaccines
can enhance immunogenicity without an adjuvant and induce a robust cytotoxic T …

Background Development of an effective vaccine against the pathogenic blood-stage
infection of human malaria has proved challenging, and no candidate vaccine has affected …

Highlights•Safety and potency of simian adenovirus vectors is now well established, most
recently in infants.•Viral vectored vaccines are effective against malaria and Ebola in field …

Background The West African outbreak of Ebola virus disease that peaked in 2014 has
caused more than 11,000 deaths. The development of an effective Ebola vaccine is a priority …

Induction of antigen-specific CD8+ T cells offers the prospect of immunization against many
infectious diseases, but no subunit vaccine has induced CD8+ T cells that correlate with …

After Edward Jenner established human vaccination over 200 years ago, attenuated
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …

African swine fever (ASF) is a lethal haemorrhagic disease of domestic pigs for which there
is no vaccine. Strains of the virus with reduced virulence can provide protection against …

Since the discovery in 1796 by Edward Jenner of vaccinia virus as a way to prevent and
finally eradicate smallpox, the concept of using a virus to fight another virus has evolved into …

Adenoviruses are potent vectors for inducing and boosting cellular immunity to encoded
recombinant antigens. However, the widespread seroprevalence of neutralizing antibodies …