Extracellular vesicles: exosomes, microvesicles, and friends
G Raposo, W Stoorvogel - Journal of Cell Biology, 2013 - rupress.org
Cells release into the extracellular environment diverse types of membrane vesicles of
endosomal and plasma membrane origin called exosomes and microvesicles, respectively …
endosomal and plasma membrane origin called exosomes and microvesicles, respectively …
Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis
LM Doyle, MZ Wang - Cells, 2019 - mdpi.com
The use of extracellular vesicles, specifically exosomes, as carriers of biomarkers in
extracellular spaces has been well demonstrated. Despite their promising potential, the use …
extracellular spaces has been well demonstrated. Despite their promising potential, the use …
Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …
Exosome-based cell-cell communication in the tumor microenvironment
J Maia, S Caja, MC Strano Moraes, N Couto… - Frontiers in cell and …, 2018 - frontiersin.org
Tumors are not isolated entities, but complex systemic networks involving cell-cell
communication between transformed and non-transformed cells. The milieu created by …
communication between transformed and non-transformed cells. The milieu created by …
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA–an ISEV position paper
The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …
RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction
Exosomes are small vesicles that are secreted from metazoan cells and may convey
selected membrane proteins and small RNAs to target cells for the control of cell migration …
selected membrane proteins and small RNAs to target cells for the control of cell migration …
A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods
The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the
early paradigm of cell replacement and differentiation as a therapeutic mechanism of action …
early paradigm of cell replacement and differentiation as a therapeutic mechanism of action …
Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …
Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells
Extracellular vesicles (EVs) are under evaluation as therapeutics or as vehicles for drug
delivery. Preclinical studies of EVs often use mice or other animal models to assess efficacy …
delivery. Preclinical studies of EVs often use mice or other animal models to assess efficacy …