Multiple molecular mechanisms to overcome multidrug resistance in cancer by natural secondary metabolites

MZ El-Readi, AM Al-Abd, MA Althubiti… - Frontiers in …, 2021 - frontiersin.org
Plant secondary metabolites (SMs) common natural occurrences and the significantly lower
toxicities of many SM have led to the approaching development and use of these …

Sanguinarine, a promising anticancer therapeutic: photochemical and nucleic acid binding properties

GS Kumar, S Hazra - RSC Advances, 2014 - pubs.rsc.org
Sanguinarine is a benzophenanthridine plant alkaloid with remarkable therapeutic utility. It
undergoes photochemical changes and also forms strong complexes with nucleic acids, the …

Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines

E Barzegar, S Fouladdel, TK Movahhed… - Iranian journal of …, 2015 - pmc.ncbi.nlm.nih.gov
Objective (s): Berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor
properties in some in vitro systems. But the effect of berberine on breast cancer has not yet …

The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants

N Inoue, T Terabayashi, Y Takiguchi-Kawashima… - Scientific reports, 2021 - nature.com
DNA replication inhibitors are utilized extensively in studies of molecular biology and as
chemotherapy agents in clinical settings. The inhibition of DNA replication often triggers …

Antileishmanial Potential of Berberine Alkaloids From Berberis glaucocarpa Roots: Molecular Docking Suggests Relevant Leishmania Protein Targets

M Alamzeb, S Ali, Mamoon-Ur-Rashid… - Natural Product …, 2021 - journals.sagepub.com
Leishmaniases are a spectrum of poverty-linked neglected parasitic diseases that are
endemic in 88 countries around the globe and affect millions of people every year. Currently …

Chemical Composition and Anti-Proliferative Properties of Bursera graveolens Essential Oil

L Monzote, GM Hill, A Cuellar… - Natural product …, 2012 - journals.sagepub.com
Bursera graveolens is a wild tree of commercial importance native to the Neotropics, which
has been widely used in folk medicine. In the present study, the chemical composition and …

Synthesis, DNA binding and docking studies of copper (II) complexes containing modified phenanthroline ligands

J Lakshmipraba, S Arunachalam… - Journal of …, 2015 - Taylor & Francis
Copper (II) complexes,[Cu (Hsal)(L)(ClO4)](where Hsal= salicylaldehyde, 1: L= dpqC=
dipyrido [3, 2-a: 2′, 3′-c](6, 7, 8, 9-tetrahydro) phenazine and 2: L= dppz= dipyrido [3, 2-a …

Synthesis and biological activity of 6-selenocaffeine: potential modulator of chemotherapeutic drugs in breast cancer cells

IL Martins, JP Miranda, NG Oliveira, AS Fernandes… - Molecules, 2013 - mdpi.com
We report the development of a new microwave-based synthetic methodology mediated by
Woollins' reagent that allowed an efficient conversion of caffeine into 6-selenocaffeine. A …

Anti-cancer drug development: computational strategies to identify and target proteins involved in cancer metabolism

L Mak, S Liggi, L Tan, K Kusonmano… - Current …, 2013 - benthamdirect.com
Cancer remains a fundamental burden to public health despite substantial efforts aimed at
develo** effective chemotherapeutics and significant advances in chemotherapeutic …

Hetero-association of aromatic molecules in aqueous solution

MP Evstigneev - International Reviews in Physical Chemistry, 2014 - Taylor & Francis
Knowledge of the physical chemistry of small molecules complexation (the hetero-
association) in aqueous solution is increasingly important in view of the rapidly emerging …