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Multiple molecular mechanisms to overcome multidrug resistance in cancer by natural secondary metabolites
Plant secondary metabolites (SMs) common natural occurrences and the significantly lower
toxicities of many SM have led to the approaching development and use of these …
toxicities of many SM have led to the approaching development and use of these …
Sanguinarine, a promising anticancer therapeutic: photochemical and nucleic acid binding properties
Sanguinarine is a benzophenanthridine plant alkaloid with remarkable therapeutic utility. It
undergoes photochemical changes and also forms strong complexes with nucleic acids, the …
undergoes photochemical changes and also forms strong complexes with nucleic acids, the …
Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines
E Barzegar, S Fouladdel, TK Movahhed… - Iranian journal of …, 2015 - pmc.ncbi.nlm.nih.gov
Objective (s): Berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor
properties in some in vitro systems. But the effect of berberine on breast cancer has not yet …
properties in some in vitro systems. But the effect of berberine on breast cancer has not yet …
The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants
N Inoue, T Terabayashi, Y Takiguchi-Kawashima… - Scientific reports, 2021 - nature.com
DNA replication inhibitors are utilized extensively in studies of molecular biology and as
chemotherapy agents in clinical settings. The inhibition of DNA replication often triggers …
chemotherapy agents in clinical settings. The inhibition of DNA replication often triggers …
Antileishmanial Potential of Berberine Alkaloids From Berberis glaucocarpa Roots: Molecular Docking Suggests Relevant Leishmania Protein Targets
Leishmaniases are a spectrum of poverty-linked neglected parasitic diseases that are
endemic in 88 countries around the globe and affect millions of people every year. Currently …
endemic in 88 countries around the globe and affect millions of people every year. Currently …
Chemical Composition and Anti-Proliferative Properties of Bursera graveolens Essential Oil
L Monzote, GM Hill, A Cuellar… - Natural product …, 2012 - journals.sagepub.com
Bursera graveolens is a wild tree of commercial importance native to the Neotropics, which
has been widely used in folk medicine. In the present study, the chemical composition and …
has been widely used in folk medicine. In the present study, the chemical composition and …
Synthesis, DNA binding and docking studies of copper (II) complexes containing modified phenanthroline ligands
J Lakshmipraba, S Arunachalam… - Journal of …, 2015 - Taylor & Francis
Copper (II) complexes,[Cu (Hsal)(L)(ClO4)](where Hsal= salicylaldehyde, 1: L= dpqC=
dipyrido [3, 2-a: 2′, 3′-c](6, 7, 8, 9-tetrahydro) phenazine and 2: L= dppz= dipyrido [3, 2-a …
dipyrido [3, 2-a: 2′, 3′-c](6, 7, 8, 9-tetrahydro) phenazine and 2: L= dppz= dipyrido [3, 2-a …
Synthesis and biological activity of 6-selenocaffeine: potential modulator of chemotherapeutic drugs in breast cancer cells
We report the development of a new microwave-based synthetic methodology mediated by
Woollins' reagent that allowed an efficient conversion of caffeine into 6-selenocaffeine. A …
Woollins' reagent that allowed an efficient conversion of caffeine into 6-selenocaffeine. A …
Anti-cancer drug development: computational strategies to identify and target proteins involved in cancer metabolism
L Mak, S Liggi, L Tan, K Kusonmano… - Current …, 2013 - benthamdirect.com
Cancer remains a fundamental burden to public health despite substantial efforts aimed at
develo** effective chemotherapeutics and significant advances in chemotherapeutic …
develo** effective chemotherapeutics and significant advances in chemotherapeutic …
Hetero-association of aromatic molecules in aqueous solution
MP Evstigneev - International Reviews in Physical Chemistry, 2014 - Taylor & Francis
Knowledge of the physical chemistry of small molecules complexation (the hetero-
association) in aqueous solution is increasingly important in view of the rapidly emerging …
association) in aqueous solution is increasingly important in view of the rapidly emerging …