Engineering whole-cell microbial biosensors: Design principles and applications in monitoring and treatment of heavy metals and organic pollutants

C Liu, H Yu, B Zhang, S Liu, C Liu, F Li, H Song - Biotechnology Advances, 2022 - Elsevier
Biosensors have been widely used as cost-effective, rapid, in situ, and real-time analytical
tools for monitoring environments. The development of synthetic biology has enabled …

Biosynthesis of monoterpenoid and sesquiterpenoid as natural flavors and fragrances

H Jiang, X Wang - Biotechnology Advances, 2023 - Elsevier
Terpenoids are a large class of plant-derived compounds, that constitute the main
components of essential oils and are widely used as natural flavors and fragrances. The …

Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals

X Wan, F Volpetti, E Petrova, C French… - Nature chemical …, 2019 - nature.com
Cell-based biosensors have great potential to detect various toxic and pathogenic
contaminants in aqueous environments. However, frequently they cannot meet practical …

Transcription-factor-based biosensor engineering for applications in synthetic biology

N Ding, S Zhou, Y Deng - ACS Synthetic Biology, 2021 - ACS Publications
Transcription-factor-based biosensors (TFBs) are often used for metabolite detection,
adaptive evolution, and metabolic flux control. However, designing TFBs with superior …

Synthetic biology enables programmable cell‐based biosensors

M Hicks, TT Bachmann, B Wang - ChemPhysChem, 2020 - Wiley Online Library
Cell‐based biosensors offer cheap, portable and simple methods of detecting molecules of
interest but have yet to be truly adopted commercially. Issues with their performance and …

Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast

ML Skjoedt, T Snoek, KR Kildegaard… - Nature chemical …, 2016 - nature.com
Whole-cell biocatalysts have proven a tractable path toward sustainable production of bulk
and fine chemicals. Yet the screening of libraries of cellular designs to identify best …

International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023

TP Burris, IMS de Vera, I Cote, CA Flaveny… - Pharmacological …, 2023 - Elsevier
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria

Y Liu, X Wan, B Wang - Nature communications, 2019 - nature.com
Transcriptional regulation by nuclease-deficient CRISPR/Cas is a popular and valuable tool
for routine control of gene expression. CRISPR interference in bacteria can be reliably …

Design of a genetically encoded biosensor to establish a high-throughput screening platform for L-cysteine overproduction

J Gao, M Du, J Zhao, N Xu, H Du, J Ju, L Wei, J Liu - Metabolic …, 2022 - Elsevier
Metabolic engineering seeks to rewire the metabolic network of cells for the efficient
production of value-added compounds from renewable substrates. However, it remains …

Synthetic biology for manipulating quorum sensing in microbial consortia

K Stephens, WE Bentley - Trends in microbiology, 2020 - cell.com
Bacteria exist as communities in diverse multispecies environments. Quorum sensing, a
process for cell–cell communication, allows individual bacteria to glean information about …