Streptococcus pneumoniae: transmission, colonization and invasion
Streptococcus pneumoniae has a complex relationship with its obligate human host. On the
one hand, the pneumococci are highly adapted commensals, and their main reservoir on the …
one hand, the pneumococci are highly adapted commensals, and their main reservoir on the …
Pathogenesis of microbial keratitis
Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and protist
pathogens. Epithelial defects and injuries are key predisposing factors making the eye …
pathogens. Epithelial defects and injuries are key predisposing factors making the eye …
Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection
Streptococcus pneumoniae is a major pathogen causing pneumonia with over 2 million
deaths annually, especially in young children and the elderly. To date, at least 98 different …
deaths annually, especially in young children and the elderly. To date, at least 98 different …
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
R Malley, P Henneke, SC Morse… - Proceedings of the …, 2003 - National Acad Sciences
Streptococcus pneumoniae is one of the leading causes of invasive bacterial disease
worldwide. Fragments of the cell wall and the cytolytic toxin pneumolysin have been shown …
worldwide. Fragments of the cell wall and the cytolytic toxin pneumolysin have been shown …
Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins
RK Tweten - Infection and immunity, 2005 - Am Soc Microbiol
The cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins that
are produced by more than 20 species from the genera Clostridium, Streptococcus, Listeria …
are produced by more than 20 species from the genera Clostridium, Streptococcus, Listeria …
Emerging concepts in the pathogenesis of the Streptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen
Streptococcus pneumoniae (the pneumococcus) is a human respiratory tract pathogen and
a major cause of morbidity and mortality globally. Although the pneumococcus is a …
a major cause of morbidity and mortality globally. Although the pneumococcus is a …
[HTML][HTML] Structural basis of pore formation by the bacterial toxin pneumolysin
The bacterial toxin pneumolysin is released as a soluble monomer that kills target cells by
assembling into large oligomeric rings and forming pores in cholesterol-containing …
assembling into large oligomeric rings and forming pores in cholesterol-containing …
The pathogenesis of streptococcal infections: from tooth decay to meningitis
TJ Mitchell - Nature Reviews Microbiology, 2003 - nature.com
The development of bacterial disease has been likened to a'molecular arms race', in which
the host tries to eliminate the bacteria, while the bacteria try to survive in the host. Although …
the host tries to eliminate the bacteria, while the bacteria try to survive in the host. Although …
Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae
AM Berry, J Yother, DE Briles, D Hansman… - Infection and …, 1989 - Am Soc Microbiol
Insertion-duplication mutagenesis was used to construct a pneumolysin-negative derivative
of Streptococcus pneumoniae. This was achieved by first transforming the nonencapsulated …
of Streptococcus pneumoniae. This was achieved by first transforming the nonencapsulated …
Pneumolysin: pathogenesis and therapeutic target
Streptococcus pneumoniae is an opportunistic pathogen responsible for widespread illness
and is a major global health issue for children, the elderly, and the immunocompromised …
and is a major global health issue for children, the elderly, and the immunocompromised …