The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Direct lineage reprogramming involves the conversion of cellular identity. Single-cell
technologies are useful for deconstructing the considerable heterogeneity that emerges …

Human tissues comprise trillions of cells that populate a complex space of molecular
phenotypes and functions and that vary in abundance by 4–9 orders of magnitude. Relying …

Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and
can be preserved in vitro in a naive inner-cell-mass-like configuration by providing …

How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …

Isolating human MEK/ERK signaling-independent pluripotent stem cells (PSCs) with naive
pluripotency characteristics while maintaining differentiation competence and (epi) genetic …

Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …

Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …

Naïve and primed pluripotent states retain distinct molecular properties, yet limited
knowledge exists on how their state transitions are regulated. Here, we identify Mettl3, an N …