Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

Conspectus The interaction of d-block metal ions (Cu, Zn, Fe, etc.) with intrinsically
disordered proteins (IDPs) has gained interest, partly due to their proposed roles in several …

Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …

Inhibitions of amyloid β (Aβ) aggregation and Aβ-haem peroxidase-like activity have
received much attention because these two symptoms can be the primary targets of …

The blood–brain barrier (BBB) is a formidable gatekeeper toward exogenous substances,
playing an important role in brain homeostasis and maintaining a healthy microenvironment …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …

Alzheimer's disease (AD) is the most common form of dementia, which is progressively
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …

Biometal dyshomeostasis and toxic metal accumulation are common features in many
neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, and …

Alzheimer's disease (AD) is the most prevalent age‐related dementia affecting millions of
people worldwide. Its main pathological hallmark feature is the formation of insoluble protein …