We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in
AD pathogenesis. More recent advances in understanding of the human genome …

The beneficial or deleterious effects of nanomedicines emerge from their complex
interactions with intracellular pathways and their subcellular fate. Moreover, the dynamic …

Expansion microscopy (ExM) is a newly developed super-resolution technique, allowing
visualization of biological targets at nanoscale resolution on conventional fluorescence …

Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …

Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs)
locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs …

Synaptic vesicle docking, priming, and fusion at active zones are orchestrated by a complex
molecular machinery. We employed hippocampal organotypic slice cultures from mice …

A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …

Misfolding of the protein α-synuclein (aS), which associates with presynaptic vesicles, has
been implicated in the molecular chain of events leading to Parkinson's disease. Here, the …

Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

Ultrafast endocytosis can retrieve a single, large endocytic vesicle as fast as 50–100 ms
after synaptic vesicle fusion. However, the fate of the large endocytic vesicles is not known …