Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Blood cultures have been the staple of clinical microbiology laboratories for well over half a
century, but gaps remain in our ability to identify the causative agent in patients presenting …

Although there are several US Food and Drug Administration (FDA)-approved/cleared
molecular microbiology diagnostics for direct analysis of patient samples, all are single …

Background: High-density lipoproteins exert pleiotropic effects including antiinflammatory,
antiapoptotic, and lipopolysaccharide-neutralizing properties. The authors assessed the …

Fast microbiological diagnostics (MDx) are needed to ensure early targeted antimicrobial
treatment in sepsis. This systematic review focuses on the impact on antimicrobial …

Although bacteria-free DNA in blood during systemic infection is mainly derived from
bacterial death, translocation of the DNA from the gut into the blood circulation (gut …

ABSTRACT Introduction: Bloodstream infections (BSIs) remain a major public health burden
worldwide, particularly in high-income countries as they are associated with a significant …

Background Advances in medicine have improved our understanding of sepsis, but it
remains a major cause of morbidity and mortality. The detection of pathogens that cause …

Several non-culture molecular (multiplex polymerase chain reaction assays, DNA
microarrays, massive parallel DNA sequencing, in situ hybridization, microbiome profiling …

Introduction. Increased plasma cell-free DNA (cfDNA) has been reported for various
diseases in which cell death and tissue/organ damage contribute to pathogenesis, including …