Management of hypertension in chronic kidney disease

D Pugh, PJ Gallacher, N Dhaun - Drugs, 2019 - Springer
Chronic kidney disease (CKD) is an increasingly prevalent condition globally and is strongly
associated with incident cardiovascular disease (CVD). Hypertension is both a cause and …

The Circadian Syndrome: is the Metabolic Syndrome and much more!

P Zimmet, K Alberti, N Stern, C Bilu… - Journal of internal …, 2019 - Wiley Online Library
Abstract The Metabolic Syndrome is a cluster of cardio‐metabolic risk factors and
comorbidities conveying high risk of both cardiovascular disease and type 2 diabetes. It is …

Circadian mechanisms of 24-hour blood pressure regulation and patterning

MH Smolensky, RC Hermida, F Portaluppi - Sleep medicine reviews, 2017 - Elsevier
In most persons, blood pressure (BP) rises slowly during late sleep, increases rapidly upon
morning awakening and commencement of diurnal activity, exhibits two–morning and …

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

MH Smolensky, RC Hermida, A Reinberg… - Chronobiology …, 2016 - Taylor & Francis
Biological processes are organized in time as innate rhythms defined by the period (τ),
phase (peak [Φ] and trough time), amplitude (A, peak-trough difference) and mean level …

Pathophysiology of the nondip** blood pressure pattern

J Huart, A Persu, JP Lengelé, JM Krzesinski… - …, 2023 - ahajournals.org
The nondip** blood pressure (BP) pattern corresponds to a disruption in the circadian BP
rhythm with an insufficient decrease in BP levels during nighttime sleep as observed using …

Chronotherapy with low-dose aspirin for prevention of complications in pregnancy

DE Ayala, R Ucieda, RC Hermida - Chronobiology international, 2013 - Taylor & Francis
Preeclampsia and gestational hypertension are major contributors to perinatal morbidity and
mortality. Several studies aimed to test the effects of low-dose aspirin (ASA) in the …

2013 Ambulatory blood pressure monitoring recommendations for the diagnosis of adult hypertension, assessment of cardiovascular and other hypertension …

RC Hermida, MH Smolensky, DE Ayala… - Chronobiology …, 2013 - Taylor & Francis
Correlation between systolic (SBP) and diastolic (DBP) blood pressure (BP) level and target
organ damage, cardiovascular disease (CVD) risk, and long-term prognosis is much greater …

Sleep, insomnia, and hypertension: current findings and future directions

SJ Thomas, D Calhoun - Journal of the American Society of Hypertension, 2017 - Elsevier
Blood pressure (BP) varies over 24 hours. During normal sleep, BP typically decreases by
10% or more. Research suggests that disordered sleep, particularly sleep deprivation and …

Mechanism of the circadian clock in physiology

J Richards, ML Gumz - American Journal of Physiology …, 2013 - journals.physiology.org
It has been well established that the circadian clock plays a crucial role in the regulation of
almost every physiological process. It also plays a critical role in pathophysiological states …

Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks

RC Hermida, DE Ayala, MH Smolensky… - Hypertension …, 2016 - nature.com
Correlation between blood pressure (BP) and target organ damage, vascular risk and long-
term patient prognosis is greater for measurements derived from around-the-clock …