Oncogenic transcription factors in the human acute leukemias
AT Look - Science, 1997 - science.org
Chromosomal translocations in the human acute leukemias rearrange the regulatory and
coding regions of a variety of transcription factor genes. The resultant protein products can …
coding regions of a variety of transcription factor genes. The resultant protein products can …
Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
SA Armstrong, JE Staunton, LB Silverman, R Pieters… - Nature …, 2002 - nature.com
Acute lymphoblastic leukemias carrying a chromosomal translocation involving the mixed-
lineage leukemia gene (MLL, ALL1, HRX) have a particularly poor prognosis. Here we show …
lineage leukemia gene (MLL, ALL1, HRX) have a particularly poor prognosis. Here we show …
[HTML][HTML] Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
E Kroon, J Krosl, U Thorsteinsdottir, S Baban… - The EMBO …, 1998 - embopress.org
Abstract Hoxa9, Meis1 and Pbx1 encode homeodomaincontaining proteins implicated in
leukemic transformation in both mice and humans. Hoxa9, Meis1 and Pbx1 proteins have …
leukemic transformation in both mice and humans. Hoxa9, Meis1 and Pbx1 proteins have …
Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
TR Bürglin - Nucleic acids research, 1997 - academic.oup.com
A new Caenorhabditis elegans homeobox gene, ceh-25, is described that belongs to the
TALE superclass of atypical homeodomains, which are characterized by three extra …
TALE superclass of atypical homeodomains, which are characterized by three extra …
Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation
M Kawamura-Saito, Y Yamazaki… - Human molecular …, 2006 - academic.oup.com
Ewing's family tumors (EFTs) are highly malignant tumors arising from bone and soft tissues
that exhibit EWS–FLI1 or variant EWS–ETS gene fusions in more than 85% of the cases …
that exhibit EWS–FLI1 or variant EWS–ETS gene fusions in more than 85% of the cases …
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
PM Ayton, ML Cleary - Genes & development, 2003 - genesdev.cshlp.org
Transcriptional deregulation through the production of dominant-acting chimeric
transcription factors derived from chromosomal translocations is a common theme in the …
transcription factors derived from chromosomal translocations is a common theme in the …
The pathogenesis of mixed-lineage leukemia
AG Muntean, JL Hess - Annual Review of Pathology …, 2012 - annualreviews.org
Aggressive leukemias arise in both children and adults as a result of rearrangements to the
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …
NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights
Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily
balanced translocations and inversions, are associated with a wide array of hematopoietic …
balanced translocations and inversions, are associated with a wide array of hematopoietic …
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
Abstract Expression of HoxaT and Hoxa9 is activated by proviral integration in BXH2 murine
myeloid leukaemias. This result, combined with the map** of the HOXA locus to human …
myeloid leukaemias. This result, combined with the map** of the HOXA locus to human …