As key developmental regulators, HOX cluster genes have varied and context-specific roles
in normal and malignant hematopoiesis. A complex interaction of transcription factors …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

Acute lymphoblastic leukemias carrying a chromosomal translocation involving the mixed-
lineage leukemia gene (MLL, ALL1, HRX) have a particularly poor prognosis. Here we show …

Chromosomal translocations in the human acute leukemias rearrange the regulatory and
coding regions of a variety of transcription factor genes. The resultant protein products can …

Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily
balanced translocations and inversions, are associated with a wide array of hematopoietic …

A new Caenorhabditis elegans homeobox gene, ceh-25, is described that belongs to the
TALE superclass of atypical homeodomains, which are characterized by three extra …

Hoxa9, Meis1 and Pbx1 encode homeodomaincontaining proteins implicated in leukemic
transformation in both mice and humans. Hoxa9, Meis1 and Pbx1 proteins have been …

Aggressive leukemias arise in both children and adults as a result of rearrangements to the
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …

Ewing's family tumors (EFTs) are highly malignant tumors arising from bone and soft tissues
that exhibit EWS–FLI1 or variant EWS–ETS gene fusions in more than 85% of the cases …

A common landmark of activated genes is the presence of trimethylation on lysine 4 of
histone H3 (H3K4) at promoter regions. Set1/COMPASS was the founding member and is …