DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …

Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of
proteins found throughout all domains of life. The hallmark of this family is a conserved …

Hijacking the cellular protein degradation system offers unique opportunities for drug
discovery, as exemplified by proteolysis-targeting chimeras. Despite their great promise for …

Bacterial transposons are pervasive mobile genetic elements that use distinct DNA-binding
proteins for horizontal transmission. For example, Escherichia coli Tn 7 homes to a specific …

Although human core body temperature is known to decrease with age, the age
dependency of facial temperature and its potential to indicate aging rate or aging-related …

Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in
non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium …

Adenosine-to-inosine RNA editing has been proposed to be involved in a bacterial anti-
phage defense system called RADAR. RADAR contains an adenosine triphosphatase …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …