Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

In image-based profiling, software extracts thousands of morphological features of cells from
multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used …

Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic
differences among a variety of cell populations. It paves the way to studying biological …

In morphological profiling, quantitative data are extracted from microscopy images of cells to
identify biologically relevant similarities and differences among samples based on these …

Identifying nuclei is often a critical first step in analyzing microscopy images of cells and
classical image processing algorithms are most commonly used for this task. Recent …

Measuring the phenotypic effect of treatments on cells through imaging assays is an efficient
and powerful way of studying cell biology, and requires computational methods for …

High-throughput image-based profiling platforms are powerful technologies capable of
collecting data from billions of cells exposed to thousands of perturbations in a time-and cost …

Genetic screens are critical for the systematic identification of genes underlying cellular
phenotypes. Pooling gene perturbations greatly improves scalability but is not compatible …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …