The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

METHODS We conducted a thorough electronic search by Cochrane, EMBASE and
PubMed to identify relevant studies. Studies published up to the end of October 2018 were …

A functional, replete T-cell repertoire is an integral component to adequate immune
surveillance and to the initiation and maintenance of productive antitumor immune …

Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …

Apoptosis by Death Factor: Cell Skip to Main Content Advertisement Cell This journal offers
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To evaluate the utility of tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) as
a cancer therapeutic, we created leucine zipper (LZ) forms of human (hu) and murine (mu) …

Despite impressive clinical success, cancer immunotherapy based on immune checkpoint
blockade remains ineffective in many patients due to tumoral resistance. Here we use the …

Despite major advances in understanding the mechanisms leading to tumor immunity, a
number of obstacles hinder the successful translation of mechanistic insights into effective …