Computational psychiatry: from synapses to sentience
This review considers computational psychiatry from a particular viewpoint: namely, a
commitment to explaining psychopathology in terms of pathophysiology. It rests on the …
commitment to explaining psychopathology in terms of pathophysiology. It rests on the …
Functional neuroimaging in psychiatry and the case for failing better
Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …
among the most debilitating and poorly understood of any medical condition. Current …
[HTML][HTML] The dysconnection hypothesis (2016)
Twenty years have passed since the dysconnection hypothesis was first proposed (Friston
and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous …
and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous …
A working model of neural activity and phenomenal experience in psychosis
M Martino, P Magioncalda - Molecular psychiatry, 2024 - nature.com
According to classical phenomenology, phenomenal experience is composed of
perceptions (related to environmental stimuli) and imagery/ideas (unrelated to …
perceptions (related to environmental stimuli) and imagery/ideas (unrelated to …
Evidence that the frontal pole has a significant role in the pathophysiology of schizophrenia
Different regions of the cortex have been implicated in the pathophysiology of
schizophrenia. Recently published data suggested there are many more changes in gene …
schizophrenia. Recently published data suggested there are many more changes in gene …
All or nothing belief updating in patients with schizophrenia reduces precision and flexibility of beliefs
Schizophrenia is characterized by abnormal perceptions and beliefs, but the computational
mechanisms through which these abnormalities emerge remain unclear. One prominent …
mechanisms through which these abnormalities emerge remain unclear. One prominent …
Volatility estimates increase choice switching and relate to prefrontal activity in schizophrenia
Background Reward-based decision making is impaired in patients with schizophrenia
(PSZ), as reflected by increased choice switching. The underlying cognitive and motivational …
(PSZ), as reflected by increased choice switching. The underlying cognitive and motivational …
Ketamine affects prediction errors about statistical regularities: a computational single-trial analysis of the mismatch negativity
The auditory mismatch negativity (MMN) is significantly reduced in schizophrenia. Notably, a
similar MMN reduction can be achieved with NMDA receptor (NMDAR) antagonists. Both …
similar MMN reduction can be achieved with NMDA receptor (NMDAR) antagonists. Both …
Models of dynamic belief updating in psychosis—a review across different computational approaches
To understand the dysfunctional mechanisms underlying maladaptive reasoning of
psychosis, computational models of decision making have widely been applied over the …
psychosis, computational models of decision making have widely been applied over the …
An active inference perspective on the negative symptoms of schizophrenia
Predictive coding has played a transformative role in the study of psychosis, casting
delusions and hallucinations as statistical inference in a system with abnormal precision …
delusions and hallucinations as statistical inference in a system with abnormal precision …