Neurotoxicity of polychlorinated biphenyls and related organohalogens

IN Pessah, PJ Lein, RF Seegal, SK Sagiv - Acta neuropathologica, 2019 - Springer
Halogenated organic compounds are pervasive in natural and built environments. Despite
restrictions on the production of many of these compounds in most parts of the world through …

Evidence implicating non-dioxin-like congeners as the key mediators of polychlorinated biphenyl (PCB) developmental neurotoxicity

C Klocke, PJ Lein - International journal of molecular sciences, 2020 - mdpi.com
Despite being banned from production for decades, polychlorinated biphenyls (PCBs)
continue to pose a significant risk to human health. This is due to not only the continued …

[HTML][HTML] Polychlorinated biphenyls (PCBs): risk factors for autism spectrum disorder?

HK Panesar, CL Kennedy, KP Keil Stietz, PJ Lein - Toxics, 2020 - mdpi.com
Autism spectrum disorder (ASD) includes a group of multifactorial neurodevelopmental
disorders defined clinically by core deficits in social reciprocity and communication …

The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences

C Klocke, S Sethi, PJ Lein - Environmental Science and Pollution …, 2020 - Springer
Although banned from production for decades, PCBs remain a significant risk to human
health. A primary target of concern is the develo** brain. Epidemiological studies link PCB …

Agricultural surface water, imidacloprid, and chlorantraniliprole result in altered gene expression and receptor activation in Pimephales promelas

SA Stinson, S Hasenbein, RE Connon, X Deng… - Science of The Total …, 2022 - Elsevier
The toxicity of single pesticides is likely underestimated when considering complex pesticide
mixtures found in agricultural runoff and this is especially true for newer pesticides with little …

Intracellular Ca2+ release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal

MH Zhu, TS Sung, K O'Driscoll… - American Journal of …, 2015 - journals.physiology.org
Interstitial cells of Cajal (ICC) provide pacemaker activity in gastrointestinal muscles that
underlies segmental and peristaltic contractions. ICC generate electrical slow waves that are …

Immunotoxicity of polychlorinated biphenyls (PCBs) to the marine crustacean species, Scylla paramamosain

C **ao, Y Zhang, F Zhu - Environmental Pollution, 2021 - Elsevier
Polychlorinated biphenyls (PCBs) are persistent organic pollutants in environments, and
they can negatively affect aquatic animal health. After 7 days of PCBs exposure, the …

Authentication of synthetic environmental contaminants and their (bio) transformation products in toxicology: polychlorinated biphenyls as an example

X Li, EB Holland, W Feng, J Zheng, Y Dong… - … Science and Pollution …, 2018 - Springer
Toxicological studies use “specialty chemicals” and, thus, should assess and report both
identity and degree of purity (homogeneity) of the chemicals (or toxicants) under …

An extended structure–activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards …

EB Holland, W Feng, J Zheng, Y Dong, X Li… - Toxicological …, 2017 - academic.oup.com
Nondioxin-like polychlorinated biphenyls (NDL PCBs) activate ryanodine-sensitive Ca2+
channels (RyRs) and this activation has been associated with neurotoxicity in exposed …