[HTML][HTML] The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy
F Ardito, M Giuliani, D Perrone… - International …, 2017 - spandidos-publications.com
Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …
Phosphorylation: implications in cancer
Post translational modifications (PTMs) are involved in variety of cellular activities and
phosphorylation is one of the most extensively studied PTM, which regulates a number of …
phosphorylation is one of the most extensively studied PTM, which regulates a number of …
Post-translational modifications in signal integration
Post-translational modifications of proteins and the domains that recognize these
modifications have central roles in creating a highly dynamic relay system that reads and …
modifications have central roles in creating a highly dynamic relay system that reads and …
[HTML][HTML] Genistein, a specific inhibitor of tyrosine-specific protein kinases.
T Akiyama, J Ishida, S Nakagawa, H Ogawara… - Journal of Biological …, 1987 - Elsevier
Tyrosine-specific protein kinase activity of the epidermal growth factor (EGF) receptor, pp60v-
src and pp110gag-fes was inhibited in vitro by an isoflavone genistein. The inhibition was …
src and pp110gag-fes was inhibited in vitro by an isoflavone genistein. The inhibition was …
[HTML][HTML] Signaling—2000 and beyond
When the history of signal transduction is written in 2100, what will be remembered of the
exciting advances that occurred in the latter half of the twentieth century? Everyone will …
exciting advances that occurred in the latter half of the twentieth century? Everyone will …
Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene
A novel potential cell surface receptor of the tyrosine kinase gene family has been identified
and characterized by molecular cloning. Its primary sequence is very similar to that of the …
and characterized by molecular cloning. Its primary sequence is very similar to that of the …
SH2 domains recognize specific phosphopeptide sequences
The discovery that Src homology 2 (SH2) domains provide phosphorylation-dependent and
sequence-specific contacts for assembly of receptor signaling complexes has provided a …
sequence-specific contacts for assembly of receptor signaling complexes has provided a …
[HTML][HTML] Tyrosine kinase–role and significance in cancer
Tyrosine kinases are important mediators of the signaling cascade, determining key roles in
diverse biological processes like growth, differentiation, metabolism and apoptosis in …
diverse biological processes like growth, differentiation, metabolism and apoptosis in …
Why nature really chose phosphate
Phosphoryl transfer plays key roles in signaling, energy transduction, protein synthesis, and
maintaining the integrity of the genetic material. On the surface, it would appear to be a …
maintaining the integrity of the genetic material. On the surface, it would appear to be a …
[HTML][HTML] Roscovitine in cancer and other diseases
Abstract Roscovitine [CY-202,(R)-Roscovitine, Seliciclib] is a small molecule that inhibits
cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site. It is a …
cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site. It is a …