[HTML][HTML] Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: rationale and therapeutic potential

Y Zhang, P Lu, H Qin, Y Zhang, X Sun, X Song… - Biomedicine & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive pulmonary interstitial inflammatory
disease of unknown etiology, and is also a sequela in severe patients with the Coronavirus …

Physical stability of dry powder inhaler formulations

N Shetty, D Cipolla, H Park, QT Zhou - Expert opinion on drug …, 2020 - Taylor & Francis
ABSTRACT Introduction: Dry powder inhalers (DPIs) are popular for pulmonary drug
delivery. Various techniques have been employed to produce inhalation drug particles and …

Leucine as an excipient in spray dried powder for inhalation

N Alhajj, NJ O'Reilly, H Cathcart - Drug Discovery Today, 2021 - Elsevier
Leucine is a promising excipient with several applications in the development of inhalable
spray-dried powder of high-and low-dose drugs. The addition of leucine has exhibited …

[HTML][HTML] Designing enhanced spray dried particles for inhalation: A review of the impact of excipients and processing parameters on particle properties

N Alhajj, NJ O'Reilly, H Cathcart - Powder Technology, 2021 - Elsevier
Spray drying is a constructive single-step manufacturing technique used to produce dry
powder. Spray drying plays a remarkable role in producing inhalable powder formulations …

Dry powder pharmaceutical biologics for inhalation therapy

RYK Chang, MYT Chow, D Khanal, D Chen… - Advanced Drug Delivery …, 2021 - Elsevier
Therapeutic biologics such as genes, peptides, proteins, virus and cells provide clinical
benefits and are becoming increasingly important tools in respiratory medicine. Pulmonary …

Engineering the right formulation for enhanced drug delivery

WR Ke, RYK Chang, HK Chan - Advanced Drug Delivery Reviews, 2022 - Elsevier
Dry powder inhalers (DPIs) can be used with a wide range of drugs such as small molecules
and biologics and offer several advantages for inhaled therapy. Early DPI products were …

[HTML][HTML] Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles

Y Xu, L Harinck, AG Lokras, P Gerde, E Selg… - International Journal of …, 2022 - Elsevier
Thermostable dry powder inhaler (DPI) formulations with high aerosol performance are
attractive inhalable solid dosage forms for local treatment of inflammatory lung diseases. We …

A comprehensive overview of dry powder inhalers for pulmonary drug delivery: Challenges, advances, optimization techniques, and applications

HI Shahin, L Chablani - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Dry powder inhaler (DPI) is an attractive dosage form for local and systemic pulmonary drug
delivery. However, designing DPIs with adequate physicochemical properties is …

Influence of excipients on physical and aerosolization stability of spray dried high-dose powder formulations for inhalation

N Shetty, H Park, D Zemlyanov, S Mangal… - International journal of …, 2018 - Elsevier
The aim of this study is to investigate the influence of excipients on physical and
aerosolization stability of spray dried Ciprofloxacin dry powder inhaler formulations. The …

Production of highly stable spray dried phage formulations for treatment of Pseudomonas aeruginosa lung infection

RY Chang, J Wong, A Mathai, S Morales… - European Journal of …, 2017 - Elsevier
The potential of bacteriophage therapy for the treatment of pulmonary infections caused by
antibiotic-resistant bacteria has been well recognised. The purpose of this study was to …