Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model

SN Langel, S Johnson, CI Martinez… - Science Translational …, 2022 - science.org
Transmission-blocking strategies that slow the spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and protect against coronavirus disease 2019 (COVID-19) are …

An easy pill to swallow: oral recombinant vaccines for the 21st century

MR Braun, BA Flitter, W Sun, SN Tucker - Current Opinion in Immunology, 2023 - Elsevier
Oral vaccines have a distinctive advantage of stimulating immune responses in the mucosa,
where numerous pathogens gain entry and cause disease. Although various efforts have …

Mucosal immunization with Ad5-based vaccines protects Syrian hamsters from challenge with omicron and delta variants of SARS-CoV-2

MR Braun, CI Martinez, EG Dora, LJ Showalter… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2 variant clades continue to circumvent antibody responses elicited by
vaccination or infection. Current parenteral vaccination strategies reduce illness and …

Modeling the potential economic benefits of an oral SARS-CoV-2 vaccine during an outbreak of COVID-19

B Patenaude, J Ballreich - BMC public health, 2022 - Springer
Background Given patient preferences, the choice of delivery modality for vaccines against
SARS-CoV-2 has the potential to significantly impact both health and economic …

A Next-Generation Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding after SARS-CoV-2 Challenge in Nonhuman …

SN Tedjakusuma, CA Lester, ED Neuhaus, EG Dora… - Vaccines, 2024 - mdpi.com
As new SARS-CoV-2 variants continue to emerge and impact communities worldwide, next-
generation vaccines that enhance protective mucosal immunity may have a significant …

Adenoviral-based vaccine elicits robust systemic and mucosal cross-reactive responses in African green monkeys and reduces shedding after SARS-CoV-2 challenge

SN Tedjakusuma, CA Lester, ED Neuhaus, EG Dora… - bioRxiv, 2022 - biorxiv.org
As new SARS-CoV-2 variants continue to emerge and impact communities worldwide,
efforts to develop next generation vaccines that enhance mucosal immunity would be …