Liquid chromatography linked to tandem mass spectrometry (LC–MS/MS) has played an
important role in pharmacokinetics and metabolism studies at various drug development …

Therapeutic Drug Monitoring (TDM) is a valid tool to optimise pharmacotherapy. It enables
the clinician to adjust the dosage of drugs according to the characteristics of the individual …

On-line solid phase extraction (SPE)–liquid chromatography (LC) allows for automated,
sensitive, precise and selective bioanalysis. It is a common feature in miniaturized-or nano …

Metabolic conversion of vitamin A (retinol) into retinoic acid (RA) controls numerous
physiological processes. 9-cis-retinoic acid (9cRA), an active metabolite of vitamin A, is a …

Abstract Analysis at trace levels, an ideal area of application for hyphenated techniques, is
steadily gaining importance. Many sample pre‐concentration and clean‐up methods have …

Standard technology for analyte detection in clinical chemistry fields rely on indirect
characteristics of an analyte, eg its absorption capability of light, chemical reactivity or …

BACKGROUND: LC-MS/MS is an almost universal technology for the quantification of small
molecules in human sample materials. The widespread use of this technology in laboratory …

In order to support drug discovery and development studies within the pharmaceutical
industry there has been an increased use of innovative bioanalytical assays and associated …

Both combinatorial chemistry and parallel synthesis provide a valuable means for the
production of large num-bers of compounds with diverse molecular architectures that …

During the last decade, quantification of low molecular weight molecules using liquid
chromatography–tandem mass spectrometry in biological fluids has become a common …