Genetic–epigenetic interactions in cis: a major focus in the post-GWAS era
Studies on genetic–epigenetic interactions, including the map** of methylation
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
PJ Hop, RAJ Zwamborn, E Hannon… - Science translational …, 2022 - science.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …
Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in
humans remains poorly understood. While DNA methylation at many CpG sites closely …
humans remains poorly understood. While DNA methylation at many CpG sites closely …
Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control
Background Genetic variants can modulate phenotypic outcomes via epigenetic
intermediates, for example at methylation quantitative trait loci (mQTL). We present the first …
intermediates, for example at methylation quantitative trait loci (mQTL). We present the first …
Decoding the non‐coding genome: elucidating genetic risk outside the coding genome
CL Barr, VL Misener - Genes, Brain and Behavior, 2016 - Wiley Online Library
Current evidence emerging from genome‐wide association studies indicates that the
genetic underpinnings of complex traits are likely attributable to genetic variation that …
genetic underpinnings of complex traits are likely attributable to genetic variation that …
Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference
Background DNA methylation is a key epigenetic modification in human development and
disease, yet there is limited understanding of its highly coordinated regulation. Here, we …
disease, yet there is limited understanding of its highly coordinated regulation. Here, we …
Autosomal genetic variation is associated with DNA methylation in regions variably esca** X-chromosome inactivation
Abstract X-chromosome inactivation (XCI), ie, the inactivation of one of the female X
chromosomes, restores equal expression of X-chromosomal genes between females and …
chromosomes, restores equal expression of X-chromosomal genes between females and …
IMAGE: high-powered detection of genetic effects on DNA methylation using integrated methylation QTL map** and allele-specific analysis
Identifying genetic variants that are associated with methylation variation—an analysis
commonly referred to as methylation quantitative trait locus (mQTL) map**—is important …
commonly referred to as methylation quantitative trait locus (mQTL) map**—is important …
Genome-wide study of DNA methylation in amyotrophic lateral sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol …
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability of around 50%. DNA methylation patterns can serve as biomarkers of (past) …
heritability of around 50%. DNA methylation patterns can serve as biomarkers of (past) …
OCEAN: Flexible Feature Set Aggregation for Analysis of Multi-omics Data
Integrated analysis of multi-omics datasets holds great promise for uncovering complex
biological processes. However, the large dimension of omics data poses significant …
biological processes. However, the large dimension of omics data poses significant …