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Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …
disease states, cells and tissues undergo constant changes in genome activity, cell fate …
Physical models of collective cell migration
Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …
Deformation and flow of amorphous solids: Insights from elastoplastic models
The deformation and flow of disordered solids, such as metallic glasses and concentrated
emulsions, involves swift localized rearrangements of particles that induce a long-range …
emulsions, involves swift localized rearrangements of particles that induce a long-range …
Dense active matter model of motion patterns in confluent cell monolayers
Epithelial cell monolayers show remarkable displacement and velocity correlations over
distances of ten or more cell sizes that are reminiscent of supercooled liquids and active …
distances of ten or more cell sizes that are reminiscent of supercooled liquids and active …
Ductile-to-brittle transition and yielding in soft amorphous materials: perspectives and open questions
Soft amorphous materials are viscoelastic solids ubiquitously found around us, from clays
and cementitious pastes to emulsions and physical gels encountered in food or biomedical …
and cementitious pastes to emulsions and physical gels encountered in food or biomedical …
A geometrically controlled rigidity transition in a model for confluent 3D tissues
The origin of rigidity in disordered materials is an outstanding open problem in statistical
physics. Previously, a class of 2D cellular models has been shown to undergo a rigidity …
physics. Previously, a class of 2D cellular models has been shown to undergo a rigidity …
Linear viscoelastic properties of the vertex model for epithelial tissues
Epithelial tissues act as barriers and, therefore, must repair themselves, respond to
environmental changes and grow without compromising their integrity. Consequently, they …
environmental changes and grow without compromising their integrity. Consequently, they …
Solid–fluid transition and cell sorting in epithelia with junctional tension fluctuations
M Krajnc - Soft Matter, 2020 - pubs.rsc.org
Tissues transition between solid-like and fluid-like behavior, which has major implications
for morphogenesis and disease. These transitions can occur due to changes in the intrinsic …
for morphogenesis and disease. These transitions can occur due to changes in the intrinsic …
A perspective on active glassy dynamics in biological systems
Dynamics is central to living systems. Many experiments in the last two decades have
revealed glassy dynamics in diverse biological systems, showing a transition between a …
revealed glassy dynamics in diverse biological systems, showing a transition between a …
Cell division and death inhibit glassy behaviour of confluent tissues
We investigate the effects of cell division and apoptosis on collective dynamics in two-
dimensional epithelial tissues. Our model includes three key ingredients observed across …
dimensional epithelial tissues. Our model includes three key ingredients observed across …