Mechanical state transitions in the regulation of tissue form and function

Y Mao, SA Wickström - Nature Reviews Molecular Cell Biology, 2024 - nature.com
From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

Physical models of collective cell migration

R Alert, X Trepat - Annual Review of Condensed Matter Physics, 2020 - annualreviews.org
Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

Deformation and flow of amorphous solids: Insights from elastoplastic models

A Nicolas, EE Ferrero, K Martens, JL Barrat - Reviews of Modern Physics, 2018 - APS
The deformation and flow of disordered solids, such as metallic glasses and concentrated
emulsions, involves swift localized rearrangements of particles that induce a long-range …

Dense active matter model of motion patterns in confluent cell monolayers

S Henkes, K Kostanjevec, JM Collinson… - Nature …, 2020 - nature.com
Epithelial cell monolayers show remarkable displacement and velocity correlations over
distances of ten or more cell sizes that are reminiscent of supercooled liquids and active …

Ductile-to-brittle transition and yielding in soft amorphous materials: perspectives and open questions

T Divoux, E Agoritsas, S Aime, C Barentin, JL Barrat… - Soft Matter, 2024 - pubs.rsc.org
Soft amorphous materials are viscoelastic solids ubiquitously found around us, from clays
and cementitious pastes to emulsions and physical gels encountered in food or biomedical …

A geometrically controlled rigidity transition in a model for confluent 3D tissues

M Merkel, ML Manning - New Journal of Physics, 2018 - iopscience.iop.org
The origin of rigidity in disordered materials is an outstanding open problem in statistical
physics. Previously, a class of 2D cellular models has been shown to undergo a rigidity …

Linear viscoelastic properties of the vertex model for epithelial tissues

S Tong, NK Singh, R Sknepnek… - PLoS computational …, 2022 - journals.plos.org
Epithelial tissues act as barriers and, therefore, must repair themselves, respond to
environmental changes and grow without compromising their integrity. Consequently, they …

Solid–fluid transition and cell sorting in epithelia with junctional tension fluctuations

M Krajnc - Soft Matter, 2020 - pubs.rsc.org
Tissues transition between solid-like and fluid-like behavior, which has major implications
for morphogenesis and disease. These transitions can occur due to changes in the intrinsic …

A perspective on active glassy dynamics in biological systems

S Sadhukhan, S Dey, S Karmakar, SK Nandi - The European Physical …, 2024 - Springer
Dynamics is central to living systems. Many experiments in the last two decades have
revealed glassy dynamics in diverse biological systems, showing a transition between a …

Cell division and death inhibit glassy behaviour of confluent tissues

DA Matoz-Fernandez, K Martens, R Sknepnek… - Soft matter, 2017 - pubs.rsc.org
We investigate the effects of cell division and apoptosis on collective dynamics in two-
dimensional epithelial tissues. Our model includes three key ingredients observed across …