Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022 - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review

D Bian, Y Wu, G Song, R Azizi, A Zamani - Stem Cell Research & Therapy, 2022 - Springer
Recently, mesenchymal stromal cells (MSCs) and also their exosome has become a game-
changing tool in the context of tissue engineering and regenerative medicine. MSCs due to …

Identification of storage conditions stabilizing extracellular vesicles preparations

A Görgens, G Corso, DW Hagey… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) play a key role in many physiological and pathophysiological
processes and hold great potential for therapeutic and diagnostic use. Despite significant …

[HTML][HTML] Dosing extracellular vesicles

D Gupta, AM Zickler, S El Andaloussi - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicles (EVs) are natural nanoparticles containing biologically active
molecules. They are important mediators of intercellular communication and can be …

The impact of storage on extracellular vesicles: A systematic study

S Gelibter, G Marostica, A Mandelli… - Journal of …, 2022 - Wiley Online Library
Mounting evidence suggests that storage has an impact on extracellular vesicles (EVs)
properties. While− 80° C storage is a widespread approach, some authors proposed …

Size and surface charge characterization of nanoparticles with a salt gradient

MK Rasmussen, JN Pedersen, R Marie - Nature communications, 2020 - nature.com
Exosomes are nanometer-sized lipid vesicles present in liquid biopsies and used as
biomarkers for several diseases including cancer, Alzheimer's, and central nervous system …

Zeta potential of extracellular vesicles: toward understanding the attributes that determine colloidal stability

G Midekessa, K Godakumara, J Ord, J Viil… - ACS …, 2020 - ACS Publications
Extracellular vesicles (EVs), including exosomes and microvesicles (< 200 nm), play a vital
role in intercellular communication and carry a net negative surface charge under …

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

KW Witwer, BWM Van Balkom, S Bruno… - Journal of …, 2019 - Taylor & Francis
Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are
transiting rapidly towards clinical applications. However, discrepancies and controversies …

New technologies for analysis of extracellular vesicles

H Shao, H Im, CM Castro, X Breakefield… - Chemical …, 2018 - ACS Publications
Extracellular vesicles (EVs) are diverse, nanoscale membrane vesicles actively released by
cells. Similar-sized vesicles can be further classified (eg, exosomes, microvesicles) based …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …