MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches
The deeper understanding of non-coding RNAs has recently changed the dogma of
molecular biology assuming protein-coding genes as unique functional biological effectors …
molecular biology assuming protein-coding genes as unique functional biological effectors …
[HTML][HTML] Targeting protein arginine methyltransferase 5 in cancers: Roles, inhibitors and mechanisms
Y Chen, X Shao, X Zhao, Y Ji, X Liu, P Li… - Biomedicine & …, 2021 - Elsevier
The protein arginine methyltransferase 5 (PRMT5) as the major type II arginine
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …
[HTML][HTML] Multiple myeloma: the (r) evolution of current therapy and a glance into the future
KC Anderson - Haematologica, 2020 - ncbi.nlm.nih.gov
Over the past 20 years, the regulatory approval of several novel agents to treat multiple
myeloma (MM) has prolonged median patient survival from 3 to 8-10 years. Increased …
myeloma (MM) has prolonged median patient survival from 3 to 8-10 years. Increased …
Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity
The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in multiple
myeloma (MM) are still to be investigated. Here, we studied the functional significance and …
myeloma (MM) are still to be investigated. Here, we studied the functional significance and …
Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma
E Taiana, V Favasuli, D Ronchetti, K Todoerti… - Leukemia, 2020 - nature.com
The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in multiple
myeloma (MM) are still open questions. Herein, we investigated the functional significance …
myeloma (MM) are still open questions. Herein, we investigated the functional significance …
Multiple myeloma: challenges encountered and future options for better treatment
Multiple myeloma (MM) is a malignant hematological disease. The disease is characterized
by the clonal proliferation of malignant plasma cells in the bone marrow. MM accounts for …
by the clonal proliferation of malignant plasma cells in the bone marrow. MM accounts for …
Protein arginine methyltransferase 5 has prognostic relevance and is a druggable target in multiple myeloma
Arginine methyltransferases critically regulate cellular homeostasis by modulating the
functional outcome of their substrates. The protein arginine methyltransferase 5 (PRMT5) is …
functional outcome of their substrates. The protein arginine methyltransferase 5 (PRMT5) is …
When oxidative stress meets epigenetics: implications in cancer development
Á García-Guede, O Vera, I Ibáñez-de-Caceres - Antioxidants, 2020 - mdpi.com
Cancer is one of the leading causes of death worldwide and it can affect any part of the
organism. It arises as a consequence of the genetic and epigenetic changes that lead to the …
organism. It arises as a consequence of the genetic and epigenetic changes that lead to the …
Myeloma bone disease: a comprehensive review
SKR Mukkamalla, D Malipeddi - International journal of molecular …, 2021 - mdpi.com
Multiple myeloma (MM) is a neoplastic clonal proliferation of plasma cells in the bone
marrow microenvironment, characterized by overproduction of heavy-and light-chain …
marrow microenvironment, characterized by overproduction of heavy-and light-chain …
Anti-tumor activity and epigenetic impact of the polyphenol oleacein in multiple myeloma
Olive oil contains different biologically active polyphenols, among which oleacein, the most
abundant secoiridoid, has recently emerged for its beneficial properties in various disease …
abundant secoiridoid, has recently emerged for its beneficial properties in various disease …