Cancer therapy with accelerated charged particles is one of the most valuable biomedical
applications of nuclear physics. The technology has vastly evolved in the past 50 years, the …

The major aim of radiation therapy is to provide curative or palliative treatment to cancerous
malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy …

There is a rising interest in develo** and utilizing arc delivery techniques with charged
particle beams, eg, proton, carbon or other ions, for clinical implementation. In this work …

Objective. 4D dose calculation (4DDC) for pencil beam scanned (PBS) proton therapy is
typically based on phase-sorting of individual pencil beams onto phases of a single …

Objective. 4D dose reconstruction in proton therapy with pencil beam scanning (PBS)
typically relies on a single pre-treatment 4DCT (p4DCT). However, breathing motion during …

Purpose Treatment of locally advanced lung cancer is limited by toxicity and insufficient local
control. Particle therapy could enable more conformal treatment than intensity modulated …

Upright positioning has seen a surge in interest recently as a means to reduce radiotherapy
(RT) cost, improve patient comfort, and, in selected cases, benefit treatment quality. In …

Objective. Investigating the aspects of proton beam delivery to track organ motion with pencil
beam scanning therapy. Considering current systems as a reference, specify requirements …

When treating moving tumors, the precise delivery of proton therapy by pencil beam
scanning (PBS) is challenged by the interplay effect. Although several 4D-optimization …

In anatomical sites affected by respiration, a proper description of respiratory motion
variability combined with methodologies able to accurately predict the impact of irregular …