The emergence of Zika virus and its new clinical syndromes

TC Pierson, MS Diamond - Nature, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health
threat because of its potential to generate explosive epidemics and ability to cause …

Biochemistry and molecular biology of flaviviruses

NJ Barrows, RK Campos, KC Liao, KR Prasanth… - Chemical …, 2018 - ACS Publications
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

Immune response to dengue and Zika

A Elong Ngono, S Shresta - Annual review of immunology, 2018 - annualreviews.org
Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV)
are human pathogens of global significance. In particular, DENV causes the most prevalent …

Evidence and possible mechanisms of rare maternal-fetal transmission of SARS-CoV-2

C Egloff, C Vauloup-Fellous, O Picone… - Journal of Clinical …, 2020 - Elsevier
While SARS-CoV-2 infection has spread rapidly worldwide, data remains scarce about the
natural history of infection in pregnant women and the risk of mother-to-fetal transmission …

Nonhuman primate models of human viral infections

JD Estes, SW Wong, JM Brenchley - Nature Reviews Immunology, 2018 - nature.com
Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share
many physiological parallels, such as highly similar immune systems, with them. Importantly …

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

AJ Hirsch, VHJ Roberts, PL Grigsby, N Haese… - Nature …, 2018 - nature.com
Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth
restriction and fetal central nervous system malformations, which are outcomes broadly …

The evolution of Zika virus from Asia to the Americas

ZY Liu, WF Shi, CF Qin - Nature Reviews Microbiology, 2019 - nature.com
Zika virus (ZIKV) was once considered an obscure member of the large and diverse family of
mosquito-borne flaviviruses, and human infections with ZIKV were thought to be sporadic …

Zika virus vaccines

P Abbink, KE Stephenson, DH Barouch - Nature Reviews Microbiology, 2018 - nature.com
The recent epidemic of Zika virus (ZIKV) in the Americas has revealed the devastating
consequences of ZIKV infection, particularly in pregnant women. Congenital Zika syndrome …

Immunobiology of acute chorioamnionitis

M Cappelletti, P Presicce, SG Kallapur - Frontiers in immunology, 2020 - frontiersin.org
Acute chorioamnionitis is characterized by neutrophilic infiltration and inflammation at the
maternal fetal interface. It is a relatively common complication of pregnancy and can have …

A human bi-specific antibody against Zika virus with high therapeutic potential

J Wang, M Bardelli, DA Espinosa, M Pedotti, TS Ng… - Cell, 2017 - cell.com
Zika virus (ZIKV), a mosquito-borne flavivirus, causes devastating congenital birth defects.
We isolated a human monoclonal antibody (mAb), ZKA190, that potently cross-neutralizes …