Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …

Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases
(HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-
regulatory elements that control patterns of gene expression in multicellular organisms …

Chromatin modifications are linked with regulating patterns of gene expression, but their
causal role and context-dependent impact on transcription remains unresolved. Here we …

Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers. We
performed exome sequencing on 113 tumor-normal pairs, yielding a mean of 82 non-silent …