Glia development and function in the nematode Caenorhabditis elegans

A Singhvi, S Shaham, G Rapti - Cold Spring Harbor …, 2024‏ - cshperspectives.cshlp.org
The nematode Caenorhabditis elegans is a powerful experimental setting for uncovering
fundamental tenets of nervous system organization and function. Its nearly invariant and …

[HTML][HTML] Photobiomodulation of neurogenesis through the enhancement of stem cell and neural progenitor differentiation in the central and peripheral nervous …

SY Chang, MY Lee - International Journal of Molecular Sciences, 2023‏ - mdpi.com
Photobiomodulation (PBM) is the regulation of biological processes using light energy from
sources such as lasers or light-emitting diodes. Components of the nervous system, such as …

[HTML][HTML] Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing

S Ray, P Gurung, RS Manning, AA Kravchuk, A Singhvi - Cell reports, 2024‏ - cell.com
Glia interact with multiple neurons, but it is unclear whether their interactions with each
neuron are different. Our interrogation at single-cell resolution reveals that a single glial cell …

Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans

CG Martin, JS Bent, T Hill, I Topalidou, A Singhvi - Developmental Cell, 2024‏ - cell.com
For an organ to maintain correct architecture and function, its diverse cellular components
must coordinate their size and shape. Although cell-intrinsic mechanisms driving homotypic …

Co-option of epidermal cells enables touch sensing

F Mangione, J Titlow, C Maclachlan, M Gho, I Davis… - Nature cell …, 2023‏ - nature.com
The epidermis is equipped with specialized mechanosensory organs that enable the
detection of tactile stimuli. Here, by examining the differentiation of the tactile bristles …

Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

MH Lee, SH Park, KM Joo, JY Kwon, KH Lee, KJ Kang - Elife, 2024‏ - elifesciences.org
Establishing transepithelial ion disparities is crucial for sensory functions in animals. In
insect sensory organs called sensilla, a transepithelial potential, known as the sensillum …

Molecular profiling of invertebrate glia

MD Purice, I Lago‐Baldaia, VM Fernandes, A Singhvi - Glia, 2025‏ - Wiley Online Library
Caenorhabditis elegans and Drosophila melanogaster are powerful experimental models
for uncovering fundamental tenets of nervous system organization and function. Findings …

Epithelia delimits glial apical polarity against mechanical shear to maintain glia-neuron-architecture

CG Martin, JS Bent, A Singhvi - BioRxiv, 2022‏ - biorxiv.org
For an organ to maintain proper architecture and function, its different component cell-types
must coordinate their cell-shapes with each other through life. While cell-intrinsic …

Developmental disorders caused by cefixime in the otic vesicles of zebrafish embryos or larvae

C Chen, X Ni, X Yin, H Chen, Y Zhou, H Sun… - … and Physiology Part C …, 2022‏ - Elsevier
To explore the developmental toxicity of cefixime (CE) in the developmental disorder and
toxicity mechanism of CE on otic vesicles, zebrafish embryos were used as an animal …

Glia in Invertebrate Models: Insights from Caenorhabditis elegans

MD Purice, LJ Severs, A Singhvi - Astrocyte-Neuron Interactions in Health …, 2024‏ - Springer
Glial cells modulate brain development, function, and health across all bilaterian animals,
and studies in the past two decades have made rapid strides to uncover the underlying …