Diabetes mellitus is a metabolic syndrome that affects millions of people worldwide. Recent
studies have demonstrated that protein kinase C (PKC) activation plays an important role in …

The availability of appropriate and reliable in vitro cell models recapitulating human
cardiovascular diseases has been the aim of numerous researchers, in order to retrace …

Increased expression of vascular cell adhesion molecule (VCAM)-1 on the activated arterial
endothelial cell (EC) surface critically contributes to atherosclerosis which may in part be …

Most cells involved in atherosclerosis release extracellular vesicles (EVs), which can carry
bioactive substances to downstream tissues via circulation. We hypothesized that EVs …

Endothelial dysfunction results in chronic vascular inflammation, which is critical for the
development of atherosclerotic diseases. Transcription factor Gata6 has been reported to …

Clinically used inhibitors of mammalian target of rapamycin (mTOR) negatively impacts
endothelial-dependent vasodilatation (EDD) through unidentified mechanisms. Here we …

Introduction: Fast food is a major risk factor for atherosclerosis, a leading cause of morbidity
and mortality in the Western world. Apelin, the endogenous adipokine, can protect against …

Atherosclerosis is the leading cause of global morbidity and mortality. Its therapy requires
research in several areas, such as diagnosis of early arteriosclerosis, improvement of the …

Metabolic syndrome is not a single pathology, but a constellation of cardiovascular disease
risk factors including: central and abdominal obesity, systemic hypertension, insulin …

Endometriosis is a common gynecological disease, which causes chronic pelvic pain and
infertility in women of reproductive age. Due to limited efficacy of current treatment options, a …