This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

The directional movement of cells can be regulated by ATP, certain other nucleotides (eg,
ADP, UTP), and adenosine. Such regulation occurs for cells that are “professional …

Objectives ST2 is a receptor for interleukin (IL)-33. We investigated an association of soluble
ST2 (sST2) and IL-33 serum levels with different clinical stages of coronary artery disease …

Cardiac fibroblasts (CFs) play an essential role in remodeling of the cardiac extracellular
matrix. Extracellular nucleotide signaling may provoke a profibrotic response in CFs. We …

Myocardial infarction (MI) is a dramatic event often caused by atherosclerotic plaque erosion
or rupture and subsequent thrombotic occlusion of a coronary vessel. The low supply of …

G-protein-coupled receptors (GPCRs) have many roles in cell regulation and are commonly
used as drug targets, but the repertoire of GPCRs expressed by individual cell types has not …

Tissue fibrosis occurs as a result of the dysregulation of extracellular matrix (ECM) synthesis.
Tissue fibroblasts, resident cells responsible for the synthesis and turnover of ECM, are …

G protein-coupled receptors are the target of more than 30% of all FDA-approved drug
therapies. Though the purinergic P2 receptors have been an attractive target for therapeutic …

Myocardial remodelling is a molecular, cellular, and interstitial adaptation of the heart in
response to altered environmental demands. The heart undergoes reversible physiological …

Fibrosis is a complex pathological process that can lead to the permanent loss of biological
function, with P2ry2 playing a crucial role in this process. Long non-coding RNAs (lncRNAs) …