[HTML][HTML] Analytical techniques for the characterization and quantification of monoclonal antibodies

HA Alhazmi, M Albratty - Pharmaceuticals, 2023 - mdpi.com
Monoclonal antibodies (mAbs) are a fast-growing class of biopharmaceuticals. They are
widely used in the identification and detection of cell makers, serum analytes, and …

Therapeutic Fc‐fusion proteins: current analytical strategies

BL Duivelshof, A Murisier, J Camperi… - Journal of separation …, 2021 - Wiley Online Library
Fc‐Fusion proteins represent a successful class of biopharmaceutical products, with already
13 drugs approved in the European Union and United States as well as three biosimilar …

Predicting antibody developability profiles through early stage discovery screening

M Bailly, C Mieczkowski, V Juan, E Metwally… - MAbs, 2020 - Taylor & Francis
Monoclonal antibodies play an increasingly important role for the development of new drugs
across multiple therapy areas. The term 'developability'encompasses the feasibility of …

Blueprint for antibody biologics developability

C Mieczkowski, X Zhang, D Lee, K Nguyen, W Lv… - MAbs, 2023 - Taylor & Francis
Large-molecule antibody biologics have revolutionized medicine owing to their superior
target specificity, pharmacokinetic and pharmacodynamic properties, safety and toxicity …

Applications of capillary electromigration methods for separation and analysis of proteins (2017–mid 2021)–a review

S Štěpánová, V Kašička - Analytica Chimica Acta, 2022 - Elsevier
This paper provides a detailed overview of relevant developments in separation and
analysis of proteins by capillary electromigration (CE) methods in the period 2017–mid …

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition

F Krebs, H Zagst, M Stein, R Ratih, R Minkner… - …, 2023 - Wiley Online Library
This review is in support of the development of selective, precise, fast, and validated
capillary electrophoresis (CE) methods. It follows up a similar article from 1998, Wätzig H …

[HTML][HTML] Antibody conjugates-recent advances and future innovations

D Leung, JM Wurst, T Liu, RM Martinez… - Antibodies, 2020 - mdpi.com
Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past
30 years. Clinical success rates of antibodies have exceeded expectations, resulting in …

Capillary electrophoresis‐mass spectrometry for intact protein analysis: Pharmaceutical and biomedical applications (2018–March 2023)

K Maráková, M Opetová… - Journal of Separation …, 2023 - Wiley Online Library
Capillary electrophoresis is recognized as a valued separation technique for its high
separation efficiency, low sample consumption, good economic and ecological aspects …

[HTML][HTML] Current green capillary electrophoresis and liquid chromatography methods for analysis of pharmaceutical and biomedical samples (2019–2023)–a review

T Jankech, I Gerhardtova, O Stefanik, P Chalova… - Analytica Chimica …, 2024 - Elsevier
Separation analytical methods, including liquid chromatography (LC) and capillary
electrophoresis (CE), in combination with an appropriate detection technique, are dominant …

Enhancement of recombinant adeno-associated virus activity by improved stoichiometry and homogeneity of capsid protein assembly

T Onishi, M Nonaka, T Maruno, Y Yamaguchi… - … Therapy Methods & …, 2023 - cell.com
Studies of recombinant adeno-associated virus (rAAV) revealed the mixture of full particles
with different densities in rAAV. There are no conclusive results because of the lack of …