Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

The accumulation of senescent cells promotes ageing and age-related diseases, but
molecular mechanisms that senescent cells use to evade immune clearance and …

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged
cells, preventing their propagation in tissues. However, senescent cells accumulate in …

Lipids are key macromolecules that perform a multitude of biological functions ranging from
maintaining structural integrity of membranes, energy storage, to signaling molecules …

A causal factor in mammalian aging is the accumulation of senescent cells (SnCs). SnCs
cause chronic inflammation, and removing SnCs decelerates aging in mice. Despite their …

Atherosclerosis is a chronic inflammatory disease of the vascular walls related to aging.
Thus far, the roles of cellular senescence and bacterial infection in the pathogenesis of …

Cellular senescence is a key process in physiological dysfunction develo** upon aging or
following diverse stressors including ionizing radiation. It describes the state of a permanent …

Hepatic fibrosis is a wound healing process which results in deposition of excessive
abnormal extracellular matrix (ECM) in response to various liver injuries. Activated hepatic …